| Entrez gene ID | | 425054 |
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| Official gene symbol | | VCX3B |
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| Full name | | variable charge, X-linked 3B |
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| Aliases | | ,MGC119815,VCX-C, |
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| Gene summary | | This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22, and the Y-linked members are two identical copies of the gene within a palindromic region on chromosome Yq11. The family members share a high degree of sequence identity, with the exception that a 30-nt unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. This family member, as represented by the reference genome allele, contains 14 copies of the 30-nt repeat unit. VCX/Y genes encode small and highly charged proteins containing putative bipartite nuclear localization signals. Although the exact function of this family member has yet to be determined, a role in mRNA stability regulation can be inferred from the ability of the highly similar family member, VCX-A, to inhibit mRNA decapping. A possible role in the regulation of ribosome assembly during spermatogenesis has also been suggested. [provided by RefSeq] |
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| Location | | Chromosome: X Locus: Xp22.31 |
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| Gene position | | 8432871 - 8434551 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 1681 bp |
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| Gene sequence |
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