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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CIITA (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID4261
Official gene symbolCIITA
Full nameclass II, major histocompatibility complex, transactivator
Aliases,C2TA,CIITAIV,MHC2TA,NLRA,
Gene summaryThis gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. [provided by RefSeq]
LocationChromosome: 16   Locus: 16p13
Gene position10971055 - 11018840  Map Viewer
Gene orientationplus
Gene size47786 bp
Gene sequence
OMIM ID600005