Entrez gene ID | | 4296 |
Official gene symbol | | MAP3K11 |
Full name | | mitogen-activated protein kinase kinase kinase 11 |
Aliases | | ,MEKK11,MGC17114,MLK-3,MLK3,PTK1,SPRK, |
Gene summary | | The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq] |
Location | | Chromosome: 11 Locus: 11q13.1-q13.3 |
Gene position | | 65381720 - 65365226 Map Viewer |
Gene orientation | | minus |
Gene size | | 16495 bp |
Gene sequence |
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OMIM ID | | 600050 |
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