Entrez gene ID | | 4317 |
Official gene symbol | | MMP8 |
Full name | | matrix metallopeptidase 8 (neutrophil collagenase) |
Aliases | | ,CLG1,HNC,MMP-8,PMNL-CL, |
Gene summary | | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq] |
Location | | Chromosome: 11 Locus: 11q22.3 |
Gene position | | 102595685 - 102582526 Map Viewer |
Gene orientation | | minus |
Gene size | | 13160 bp |
Gene sequence |
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OMIM ID | | 120355 |
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