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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for MMP8 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID4317
Official gene symbolMMP8
Full namematrix metallopeptidase 8 (neutrophil collagenase)
Aliases,CLG1,HNC,MMP-8,PMNL-CL,
Gene summaryProteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq]
LocationChromosome: 11   Locus: 11q22.3
Gene position102595685 - 102582526  Map Viewer
Gene orientationminus
Gene size13160 bp
Gene sequence
OMIM ID120355