Database of mammalian genes
Home

Home Search Browse RAGs User guide FAQs Links Questions Contribute

Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for MMP13 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID4322
Official gene symbolMMP13
Full namematrix metallopeptidase 13 (collagenase 3)
Aliases,CLG3,MANDP1,
Gene summaryProteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq]
LocationChromosome: 11   Locus: 11q22.3
Gene position102826463 - 102813721  Map Viewer
Gene orientationminus
Gene size12743 bp
Gene sequence
OMIM ID600108