Entrez gene ID | | 4326 |
Official gene symbol | | MMP17 |
Full name | | matrix metallopeptidase 17 (membrane-inserted) |
Aliases | | ,MT4-MMP, |
Gene summary | | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene is considered a member of the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMP's in that it is a GPI-anchored protein rather than a transmembrane protein. The protein activates MMP-2 by cleavage. [provided by RefSeq] |
Location | | Chromosome: 12 Locus: 12q24.3 |
Gene position | | 132312941 - 132336316 Map Viewer |
Gene orientation | | plus |
Gene size | | 23376 bp |
Gene sequence |
| |
OMIM ID | | 602285 |
|