Entrez gene ID | | 4488 |
Official gene symbol | | MSX2 |
Full name | | msh homeobox 2 |
Aliases | | ,CRS2,FPP,HOX8,MSH,PFM,PFM1, |
Gene summary | | This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2. [provided by RefSeq] |
Location | | Chromosome: 5 Locus: 5q34-q35 |
Gene position | | 174151575 - 174157902 Map Viewer |
Gene orientation | | plus |
Gene size | | 6328 bp |
Gene sequence |
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OMIM ID | | 123101 |
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