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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ZFHX3 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID463
Official gene symbolZFHX3
Full namezinc finger homeobox 3
Aliases,ATBF1,ATBT,
Gene summaryThis gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene. [provided by RefSeq]
LocationChromosome: 16   Locus: 16q22.3-q23.1
Gene position73092534 - 72816784  Map Viewer
Gene orientationminus
Gene size275751 bp
Gene sequence
OMIM ID104155