Entrez gene ID | | 4752 |
Official gene symbol | | NEK3 |
Full name | | NIMA (never in mitosis gene a)-related kinase 3 |
Aliases | | ,HSPK36,MGC29949, |
Gene summary | | This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms have been found for this gene. |
Location | | Chromosome: 13 Locus: 13q14.13 |
Gene position | | 52733996 - 52706779 Map Viewer |
Gene orientation | | minus |
Gene size | | 27218 bp |
Gene sequence |
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OMIM ID | | 604044 |
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