| Entrez gene ID | | 4772 |
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| Official gene symbol | | NFATC1 |
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| Full name | | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 |
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| Aliases | | ,MGC138448,NF-ATC,NFAT2,NFATc, |
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| Gene summary | | The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq] |
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| Location | | Chromosome: 18 Locus: 18q23 |
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| Gene position | | 77155772 - 77289323 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 133552 bp |
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| Gene sequence |
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| OMIM ID | | 600489 |
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