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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for NFKB2 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 4791 Official gene symbol NFKB2 Full name nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) Aliases ,LYT-10,LYT10,p52, Gene summary NF-kappa-B has been detected in numerous cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. NF-kappa-B is activated by a wide variety of stimuli, such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NF-kappa-B has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. In contrast, complete and persistent inhibition of NF-kappa-B has been linked directly to apoptosis, inappropriate immune cell development, and delayed cell growth. NFKB1 (MIM 164011) and NFKB2 encode p105 and p100 proteins that are processed to produce the active p50 and p52 NF-kappa-B subunits, respectively. However, the p100 and p105 proteins serve regulatory functions and should not be considered exclusively as precursor forms. The most abundant activated form of NF-kappa-B is a heterodimer of the p50 or p52 subunit bound to the RELA subunit (MIM 164014). Other NF-kappa-B complexes, consisting of hetero- and homodimers of p50, p52, RELA, REL (MIM 164910), and RELB (MIM 604758), have also been detected. NF-kappa-B complexes are inhibited by I-kappa-B proteins, NFKBIA (MIM 164008) or NFKBIB (MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by the kinases IKBKA (CHUK; MIM 600664) or IKBKB (MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. The activated NF-kappa-B complex translocates into the nucleus and binds DNA at kappa-B-binding motifs, such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). For reviews, see Chen et al. (1999) [PubMed 9895331] and Baldwin (1996) [PubMed 8717528].[supplied by OMIM] Location Chromosome: 10   Locus: 10q24 Gene position 104154229 - 104162281  Map Viewer Gene orientation plus Gene size 8053 bp Gene sequence >NFKB2:54958693..54966745:Length=8053 GGAATTCCCCCCTCCGGGGGGCCGAGAAGGGGCTTTCCCGGCCCTGAGCCCTGCTGGCAG GCGAGGTGTCGCGACCGGTCCCAGGTGGGTCGGGCGCGGAGAGAAGCCGCAACCAGAGCC GCCGCCACGGTGAGTGGCTGGATTCAGACCCCTGGGTGGCCGGGACAAGAGAAAAGAGGG AGGAGGGCCTTTAGCGGACAGCGCCTGGGGCTGGAGAGCAGCAGCTGCACACAGCCGGAA AGGGCGCGCAGGCGACGACACTCGGATCCACGTCGACACCGTTGTACAAAGATACGCGGA CCCGTACGTACACCTGTACCTGTGCTGGCGCACACACGGCAGCGTCCGTGCAGTCGCACT CGCACACACATGCACACGGAGACGTGCCCACCGGTGCACTGGTGCCTGCACCCACACCCT TCACGCACAAACTCAAGATACGCTCACCCGTGTCCGTACATCAAGACAGGCGCTGACACA CACCCACACTGAGAAGCTCGGGATTCACCTATCTACACACATGCTCGCTTGCACACTCAT GTTGACGCCATGGACACACAACATGCAACCAAGCACTACAGCCGAAACACACTTGTGGAG CTGTGATGGAGACACACTCTTGTATTAGGTGGGGGGGGGGGGGGGGGAGCGTGCAGAGAT CTCCCTGTCGCCTGCGCGCCCAGAACCGGTGCGGTGTGGGACCAGCTGCTGTTGTGAGGT TTGGGAGAGAGAGAAAAGAGCCCACTCCGAGGAGGAGACACTTTTCCCGCAGCCCCAGAA TCGCGTTCTCGGGGCAGAACCCCGGGGCCTCCCACAGGAAAGAGCCCCCGCCTACAGGCT GTTCGAAGGGGAGGCCGTCCGACAGCAGGAATGTCCCCCCAAAAGCCCCCGGGGTTTATC AGCCGTGGCCTCCCTCCTGGCAGAAAATCCCAAGGTTGCTCCAGACCGGGGGAGGGGAGC GGGAGGCGGACTTGGCCCCAGACTGCCAGCCTCCTCCCGGCCGTGAAAGACCCTCCTGTT CCCTGCCCTGGAGGGAGGAGGGGGCTTAACCCCCACCGGGGCTTCCCGGATTCTCCTAGA CCTCTGCCCGCTGAAAAGCAGCGGGAGCCCGTAGACTGTCGAGGGCCTCCCGCCCCTCCC GTCGCGAGGGCGGGGCCAGTGGCGTCATTTCCAGGCCCGCCCCCTCCGGCCCCGCCTCCC CTTGGTATTTTCGGGACTTTCCTAAGCTGCTCTAACTTTCCTGCCCCTTCCCCGGCCAAG CCCAACTCCGGATCTCGCTCTCCACCGGATCTCACCCGCCACACCCGGACAGGCGGCTGG AGGAGGTCGGACCCTCCCCCAAATCTGGGCCCCCATCTCCCGCCCACCCCCATTTAGATC TGACCCCCTCCCCCACGCCACTCCTCCCAACTTTAGGCGGGCGTCTAAAATTCTGGGAAG CAGAACCTGGCCGGAGCCACTAGACAGAGCCGGGCCTAGCCCAGAGACATGGAGAGTTGC TACAACCCAGTGAGTCATGCCGCCTGCCCCTGACCCGGCCGGCTGCCCCTCGTGTCTGTC CACCTGTCTGCCCGAGCCCCCTCTGCTGCCTTACACCTGTATGCTCGCAGATGCTCTCAG CCTGCCAGTCTGTCCATCTGTCTGCAACTCTGCCTCCAAAAGGAGCTTTCTCTTGGGTCT GAGGAGGAGGGGGGAGTGACCACTGAAGACTTGGAGATGGGAGGTGGGGCTGTGGGGGGT GCTGAGAGTCGGATGCCACCCCCAGTCTGTCTCCAAACCAGGGTCTGGATGGTATTATTG AATATGATGATTTCAAATTGAACTCCTCCATTGTGGAACCCAAGGAGCCAGCCCCAGAAA CAGGTCAGCAAGTTCACTAACCTCCCCTAGTCCTAAAGCGGGGGAGGGAGAGCATGTGCC CTCTCTCTGGGGGAGGGGCTGGGAGATCGTGGCTCAGCAAGGTCTCTCTGTCCCCAGCTG ATGGCCCCTACCTGGTGATCGTGGAACAGCCTAAGCAGGTGAGTGAGCAAAAGGGAGGGT GTGGAATGGCTTCAGCTTTGGGGACAAATGGGGTAGTGGTAGCTGGCTGGCCATGGAGGA GCCATTGCCGAAGGAGGCCACAGGGGATTGGATGGTCACTGCTGCTGATCAGAGTGCTGT AGTTTGGTTCAGGGCTACTACCAGGCACTGCGGTCACTGCTGGCCTGGGTGGTCTTCCCT GATCACAATGCTACTATGCCCTTGGACCTTCAGAGAGGCTTCCGATTTCGATATGGCTGT GAAGGCCCCTCCCATGGAGGACTGCCCGGTGCCTCCAGTGAGAAGGGCCGAAAGACCTAT CCCACTGTCAAGGTGAGCCAGGATGGTGCTGGAGGGTGGGCTAAGTGGACAGCATGCCCA AGGCCCTGACTGACAGTCCCTGCCTCTCCTAGATCTGTAACTACGAGGGACCAGCCAAGA TCGAGGTGGACCTGGTAACACACAGTGACCCACCTCGTGCTCATGCCCACAGTCTGGTGG GCAAGCAATGCTCGGAGCTGGGGATCTGCGCCGTTTCTGTGGGGCCCAAGGACATGACTG CCCAGTAGGTGCCCTCTACGCCTGGCCCCCACTGGTATGCCCGTCTGCCAGTCCCAGGCC CCAGCCCACCTCCATGAGCTTAGCATCTGACCAAGGGGAAAGATGTAGGTTGGCCCCAAA CCCAAGGGCCTAAGTAGAAACTCCAATGGCTTCCTTGAGGAAGTAAGGCTGAGCTGAGCC CTGGCAATGGGAAAGGTGCCTCAGGAAGAAAGAACTGCATGGCCAAAGGCCTCCGATTCT CTCTTCTCAGATTTAACAACCTGGGTGTCCTGCATGTGACTAAGAAGAACATGATGGGGA CTATGATACAAAAACTTCAGAGGCAGCGGCTCCGCTCTAGGCCCCAGGGCCTTACGGGTA TGGGTGCAGGGGGTGGGTCGGGTATGGGTGCAGGGGGTGGGTGGGTCATGGGAGGTGCTC ATGGAAGGAGCAGGGAGGGAGAAGCCCAGGGGTCACACATGTACCTACTGCCCAGAGGCC GAGCAGCGGGAGCTGGAGCAAGAGGCCAAAGAACTGAAGAAGGTGATGGATCTGAGTATA GTGCGGCTGCGCTTCTCTGCCTTCCTTAGAGCCAGTGATGGCTCCTTCTCCCTGCCCCTG AAGCCAGTCATCTCCCAGCCCATCCATGACAGCAGTGAGTATCCTGATTGCCTGGGGTGC CAGGCCTGGTGGCAGAGGTGGCATGAGGGGTGACCTCAAGCTGTGCAGTCAAACAGACCC AGGTTTCAGAACCTGGCCCTGCCACATATGAGCTGAGTGATCCTGAGCAAGTCATTTCCC CCCCGAAGCTTCTGTCTTTAGTAAATGTGTATATTGGGTGTTTCCTGCAGCTCCAGGGGT TGCTGAGATAAGGAATACAAAGCCCCCAGCTTCTTAAATGTGGCCTTGGCTATTGCATCA TCTCAACTAATCCATATCCCACTCCATAGAATCTCCGGGGGCATCAAACCTGAAGATTTC TCGAATGGACAAGACAGCAGGCTCTGTGCGGGGTGGAGATGAAGTTTATCTGCTTTGTGA CAAGGTGCAGAAAGGTGAGACTGGAGCCCACTTTGGGCACCAAGGACATCGAGTATAAGA CTGGGGCCAGGGAAGCTCTAGGGTAAATGGCCCCAGAGATTCCACCGGGAGCTGTGGCCA AGCTTCCGTTTTCCTTGTAGATGACATTGAGGTTCGGTTCTATGAGGATGATGAGAATGG ATGGCAGGCCTTTGGGGACTTCTCTCCCACAGATGTGCATAAACAGGTACCCAGGGCTAG GGCCCGGGCCCGGGCTGGGGGCTAAATTAGGCTAAGGACTCACTGACACCCTGTGTCTCC CTGCACCCCCCAGTATGCCATTGTGTTCCGGACACCCCCCTATCACAAGATGAAGATTGA GCGGCCTGTAACAGTGTTTCTGCAACTGAAACGCAAGCGAGGAGGGGACGTGTCTGATTC CAAACAGTTCACCTATTACCCTCTGGTGGAAGGTGGAGCTGGGCTGAGGACCTCAGGGTG CTGGCGGGGGGCCAGGCTGGGCTAGAAGAAGGTCCCAAGAGCTAGATGTGGGGATGCATG AGCCAAGTCAGAAGTGCGAGGGTCCCAGGAGGTGCTTCCTAGGAGCCGGCCCTGAGGGCT CTTCTGGGAAGGGCCCCTGAGGCATGACACAATAACTGGGCTCAATCTCATTTTCCTCTG CCCCCAGACAAGGAAGAGGTGCAGCGGAAGCGGAGGAAGGCCTTGCCCACCTTCTCCCAG CCCTTCGGGGGTGGCTCCCACATGGGTGGAGGCTCTGGGGGTGCAGCCGGGGGCTACGGA GGAGCTGGAGGAGGTGAGGGGGTACTGATGGAGGGAGGGGTAAAGGTAAGAGAAGCTGTG GAGGAAAAAAATCTGGGGGAGGCCGGGCGTGGTGGCTCACGCCTGTAATCCAGCCCTTTG GGAGGCCAAGGCAGGCAGATTACCTGAGATCAGGAGTTCAAGACCAGCTTGGCCAACAGC GTGAAACCTCGTCTCTACTAAAAATACAAACATTAGCTGGGCATGGTGGCAGGCGCCTGT AATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCTGGGAGACAAGAGG TTGCAGTAAGCTGAGATCACACCACTGCACTCCAGGCTGGGCAATAAGAGCGAAACTCCG TCTCAAAAAAAAAAAAAAAAAATCTGGGAGAGTCATGGCTGGTGCCCGCTTCCCACAGCC CTGCCTGTATCCACAGGTGGCAGCCTCGGTTTCTTCCCCTCCTCCCTGGCCTACAGCCCC TACCAGTCCGGCGCGGGCCCCATGGGCTGCTACCCGGGAGGCGGGGGCGGGGCGCAGATG GCCGCCACGGTGCCCAGCAGGGACTCCGGGGAGGAAGCCGCGGAGCCAAGCGCCCCCTCC AGGACCCCCCAGTGCGAGCCGCAGGCCCCGGAGATGCTGCAGCGAGGTATGGACTCCGGG GCACGGGCGGTCGGGGCGCCGGGGCTGAGGACCTAGCCCTGACCCACGCCCTCTGTGGCC CGTAGCTCGAGAGTACAACGCGCGCCTGTTCGGCCTGGCGCAGCGCAGCGCCCGAGCCCT ACTCGACTACGGCGTCACCGCGGACGCGCGCGCGCTGCTGGCGGGACAGCGCCACCTGCT GACGGCGCAGGACGAGAACGGAGACACGTAGGCAACAGAGGGCCTGGCGGACGAGGCGCG GGGTGGGGGCAGGAAAGGGACCGGCACGGAGGCGGGCTCTGCAGTTTTCGGACACGCCAG GCTTCAAGTCCGGCCTCGGTGTTCACAAGCTCTGTTCAAGCTGCTTGGTCTCTCCAAACT TCAGTTTGGTCGACCGTGCAAGGGGTACAGTCATAGCACTTACCTACCTCAAAAGGTGCT GCGAAACGTTAAGTGCAGGCACAGCGATGCCCTGGGCCACGTGCTGGGTTCCATGGGCCC CAGCGAGGGAGACTATGAGGGCGGTGGGGCCTTGAAAGCGAAGGATGCTCTGAGTGGCTG GGCCAGACTCTCGCTCCCCAACCCCCAGACCACTGCACCTAGCCATCATCCACGGGCAGA CCAGTGTCATTGAGCAGATAGTCTATGTCATCCACCACGCCCAGGACCTCGGCGTTGTCA ACCTCACCAACCACCTGCACCAGGTGCGGGGGCGCCTACTGGGGAGGTGGGAGGGGTTGG AAGGCAAGTGGGTCTCGGGCCTGGCTCACCCTGCTTTCATCCCCAGACGCCCCTGCACCT GGCGGTGATCACGGGGCAGACGAGTGTGGTGAGCTTTCTGCTGCGGGTAGGTGCAGACCC AGCTCTGCTGGATCGGCATGGAGACTCAGCCATGCATCTGGCGCTGCGGGCAGGCGCTGG TGCTCCTGAGCTGCTGCGTGCACTGCTTCAGAGTGGAGCTCCTGCTGTGCCCCAGCTGTT GCATATGCCTGACTTTGAGGGTGAGCTCCCCATCTCACCTGACTAAGGGGGCAGGCGGGG ACCAGGGAGGGTATCTGGCCAGTGCCCAGAATGGACTATGAGGTGTCGAGATTGAATGGT CAGGGCTGGTCCAGGGGCTGCCTTAAGGGTCACAGCTGCAGGTTGAGCATCCTGCATCCT TAGGACTGTATCCAGTACACCTGGCAGTCCGAGCCCGAAGCCCTGAGTGCCTGGATCTGC TGGTGGACAGTGGGGCTGAAGTGGAGGCCACAGAGCGGCAGGGGGGACGAACAGCCTTGC ATCTAGCCACAGAGATGGAGGAGCTGGGGTTGGTCACCCATCTGGTCACCAAGGTGGGAC TGAGGATTGTGGAAGGAGTGGGGCCAAGGGTGGTGGAGGGGCCAAAGATGGTGAAGGGGG GGGCTGGCCAAGGGGACCATGCTGTGGTGTCAACTCTCGCTGCTCGCACCCCCAGCTCCG GGCCAACGTGAACGCTCGCACCTTTGCGGGAAACACACCCCTGCACCTGGCAGCTGGACT GGGGTACCCGACCCTCACCCGCCTCCTTCTGAAGGCTGGTCAGTCTCACCCTCAGGGGCA CTTGAACAGGGTGGGGGGAAGGGAGAGAGGTGCCTCCCAGTCCCCCGACTTTGCAGTCCT TAATGTAGGCCCCCACCATACCGCCCCATGACGGCCTCCCTCTCCCAGGTGCTGACATCC ATGCTGAAAACGAGGAGCCCCTGTGCCCACTGCCTTCACCCCCTACCTCTGATAGCGACT CGGACTCTGAAGGGCCTGAGAAGGACACCCGAAGCAGCTTCCGGGGCCACACGCCTCTTG ACCTCACTTGCAGCACCAAGGTGAGGCCAGCCCGGGACTAGAAGTGCTCTGAGTGACGGG GTCCAGAGTATCTGGACTTAAAGACACAGGCTTAAGGACGAGGTGGGAGGTAGTCAGAAC TGCGGCTGTCTCCCCAGGTGAAGACCTTGCTGCTAAATGCTGCTCAGAACACCATGGAGC CACCCCTGACCCCGCCCAGCCCAGCAGGTGAGAAGCATCAGGCATCCCCAGCCCGACTCC TCTGACTCCTCACAGAGGTCTCTTCTCCTTCAGGACCTCTGAAGGAGGCCTCCCTTTCTC TACCCTCAGCCCCGTCCATCACCCCTCATGGTCCTGTCTGTCGCTTACCTTGGGAGAAAG GCAGTGTTCAGGTGTCCATGTCCCCACCCAACTCTGGAGGTAAATGACATGTCTGTATGT GTGTCCCCCTAAGGGCCGGGACTGTCACTTGGTGATACAGCTCTGCAGAACCTGGAGCAG CTGCTAGACGGGCCAGAAGCCCAGGGCAGCTGGGCAGAGCTGGCAGAGCGTCTGGGGCTG CGCAGCCTGGTAGACACGTACCGACAGACAACCTCACCCAGTGGCAGCCTCCTGCGCAGC TACGAGGTGGGTTGGCCTGTGCCCTGCCCCCTCCCCAGCCTCCTTTCCCGATCTGAGTCC AGGTGCCTCCTTGGCCCCAGGGCTCCCGAGCACATGCCCTAACCATGACTCAGACCTCAT TCCTCTGTCTTCTCAGCTGGCTGGCGGGGACCTGGCAGGTCTACTGGAGGCCCTGTCTGA CATGGGCCTAGAGGAGGGAGTGAGGCTGCTGAGGGGTCCAGAAACCCGAGACAAGCTGCC CAGCACAGGTAAAGGGGCCTCCCTGGAAGGTGGATCTGGACCTGGAGGGCCGGAGGCCTG AGGCTTTGACTATCCCATTCCTGTCCCCATTTACCCCCAGCAGAGGTGAAGGAAGACAGT GCGTACGGGAGCCAGTCAGTGGAGCAGGAGGCAGAGAAGCTGGGCCCACCCCCTGAGCCA CCAGGAGGGCTCTGCCACGGGCACCCCCAGCCTCAGGTGCACTGACCTGCTGCCTGCCCC CAGCCCCCTTCCCGGACCCCCTGTACAGCGTCCCCACCTATTTCAAATCTTATTTAACAC CCCACACCCACCCCTCAGTTGGGACAAATAAAGGATTCTCATGGGAAGGGGAGGACCCCT CCTTCCCAACTTA OMIM ID 164012