Entrez gene ID | | 4800 |
Official gene symbol | | NFYA |
Full name | | nuclear transcription factor Y, alpha |
Aliases | | ,CBF-A,CBF-B,FLJ11236,HAP2,NF-YA, |
Gene summary | | The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq] |
Location | | Chromosome: 6 Locus: 6p21.3 |
Gene position | | 41040707 - 41070146 Map Viewer |
Gene orientation | | plus |
Gene size | | 29440 bp |
Gene sequence |
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OMIM ID | | 189903 |
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