Entrez gene ID | | 4881 |
Official gene symbol | | NPR1 |
Full name | | natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) |
Aliases | | ,ANPRA,ANPa,GUC2A,GUCY2A,NPRA, |
Gene summary | | Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM] |
Location | | Chromosome: 1 Locus: 1q21-q22 |
Gene position | | 153651164 - 153666468 Map Viewer |
Gene orientation | | plus |
Gene size | | 15305 bp |
Gene sequence |
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OMIM ID | | 108960 |
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