Entrez gene ID | | 4914 |
Official gene symbol | | NTRK1 |
Full name | | neurotrophic tyrosine kinase, receptor, type 1 |
Aliases | | ,DKFZp781I14186,MTC,TRK,TRK1,TRKA,Trk-A,p140-TrkA, |
Gene summary | | This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq] |
Location | | Chromosome: 1 Locus: 1q21-q22 |
Gene position | | 156785542 - 156851642 Map Viewer |
Gene orientation | | plus |
Gene size | | 66101 bp |
Gene sequence |
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OMIM ID | | 191315 |
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