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Gene information for OAS2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID4939
Official gene symbolOAS2
Full name2'-5'-oligoadenylate synthetase 2, 69/71kDa
Aliases,MGC78578,
Gene summaryThis gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq]
LocationChromosome: 12   Locus: 12q24.2
Gene position113416274 - 113449528  Map Viewer
Gene orientationplus
Gene size33255 bp
Gene sequence
OMIM ID603350