Entrez gene ID | | 5045 |
Official gene symbol | | FURIN |
Full name | | furin (paired basic amino acid cleaving enzyme) |
Aliases | | ,FUR,PACE,PCSK3,SPC1, |
Gene summary | | The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. Some of its substrates are: proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene is thought to play a role in tumor progression. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq] |
Location | | Chromosome: 15 Locus: 15q26.1 |
Gene position | | 91411885 - 91426687 Map Viewer |
Gene orientation | | plus |
Gene size | | 14803 bp |
Gene sequence |
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OMIM ID | | 136950 |
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