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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ARHGEF3 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID50650
Official gene symbolARHGEF3
Full nameRho guanine nucleotide exchange factor (GEF) 3
Aliases,DKFZp434F2429,FLJ98126,GEF3,MGC118905,STA3,XPLN,
Gene summaryRho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
LocationChromosome: 3   Locus: 3p21-p13
Gene position57113336 - 56761446  Map Viewer
Gene orientationminus
Gene size351891 bp
Gene sequence
OMIM ID612115