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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PC (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5091
Official gene symbolPC
Full namepyruvate carboxylase
Aliases,PCB,
Gene summaryThis gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq]
LocationChromosome: 11   Locus: 11q13.4-q13.5
Gene position66725847 - 66615997  Map Viewer
Gene orientationminus
Gene size109851 bp
Gene sequence
OMIM ID608786