Entrez gene ID | | 51091 |
Official gene symbol | | SEPSECS |
Full name | | Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase |
Aliases | | ,DKFZp434B1417,LP,MGC161491,SLA,SLA/LP, |
Gene summary | | The 21st amino acid, selenocysteine (sec), is distinct from other amino acids because it lacks its own tRNA synthetase and is the only amino acid synthesized on its cognate tRNA. Synthesis of sec begins with acylation of tRNA(sec) (TRSP; MIM 165060) by seryl-tRNA synthetase (SARS; MIM 607529) to give ser-tRNA(sec), which is subsequently phosphorylated by O-phosphoseryl-tRNA kinase (PSTK; MIM 611310) to give O-phosphoseryl-tRNA(sec). SEPSECS catalyzes the final step of sec synthesis by converting O-phosphoseryl-tRNA(sec) to selenocysteinyl-tRNA(sec) using selenophosphate as the selenium donor (Palioura et al., 2009 [PubMed 19608919]).[supplied by OMIM] |
Location | | Chromosome: 4 Locus: 4p15.2 |
Gene position | | 25162204 - 25121627 Map Viewer |
Gene orientation | | minus |
Gene size | | 40578 bp |
Gene sequence |
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OMIM ID | | 613009 |
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