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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CLDN18 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID51208
Official gene symbolCLDN18
Full nameclaudin 18
Aliases,SFTA5,SFTPJ,
Gene summaryThis gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]
LocationChromosome: 3   Locus: 3q22.3
Gene position137717658 - 137752494  Map Viewer
Gene orientationplus
Gene size34837 bp
Gene sequence
OMIM ID609210