Entrez gene ID | | 51433 |
Official gene symbol | | ANAPC5 |
Full name | | anaphase promoting complex subunit 5 |
Aliases | | ,APC5, |
Gene summary | | This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq] |
Location | | Chromosome: 12 Locus: 12q24.31 |
Gene position | | 121792012 - 121746048 Map Viewer |
Gene orientation | | minus |
Gene size | | 45965 bp |
Gene sequence |
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OMIM ID | | 606948 |