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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PDE8A (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5151
Official gene symbolPDE8A
Full namephosphodiesterase 8A
Aliases,FLJ16150,HsT19550,
Gene summaryPhosphodiesterases (PDEs) regulate the intracellular levels of cAMP and cGMP. These cyclic nucleotides play an important role as second messengers in multiple physiologic processes, including regulation of vascular resistance, cardiac output, visceral motility, immune response, inflammation, neuroplasticity, vision, and reproduction. PDEs comprise a large superfamily of enzymes divided into 10 families. Different PDEs can be distinguished by their structure, tissue expression, localization, substrate specificity, regulation, and sensitivity to PDE inhibitors. Diversity in structure and specificity of function make PDEs promising targets for the pharmacotherapy of diseases modulated by cyclic nucleotide signaling (Hetman et al., MIM 2000). See MIM 171885.[supplied by OMIM]
LocationChromosome: 15   Locus: 15q25.3
Gene position85525205 - 85682373  Map Viewer
Gene orientationplus
Gene size157169 bp
Gene sequence
OMIM ID602972