Entrez gene ID | | 5156 |
Official gene symbol | | PDGFRA |
Full name | | platelet-derived growth factor receptor, alpha polypeptide |
Aliases | | ,CD140A,MGC74795,PDGFR2,RHEPDGFRA, |
Gene summary | | This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes. [provided by RefSeq] |
Location | | Chromosome: 4 Locus: 4q11-q13 |
Gene position | | 55095264 - 55164412 Map Viewer |
Gene orientation | | plus |
Gene size | | 69149 bp |
Gene sequence |
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OMIM ID | | 173490 |