Entrez gene ID | | 5159 |
Official gene symbol | | PDGFRB |
Full name | | platelet-derived growth factor receptor, beta polypeptide |
Aliases | | ,CD140B,JTK12,PDGFR,PDGFR1, |
Gene summary | | This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq] |
Location | | Chromosome: 5 Locus: 5q31-q32 |
Gene position | | 149535422 - 149493402 Map Viewer |
Gene orientation | | minus |
Gene size | | 42021 bp |
Gene sequence |
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OMIM ID | | 173410 |
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