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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PDGFRB (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5159
Official gene symbolPDGFRB
Full nameplatelet-derived growth factor receptor, beta polypeptide
Aliases,CD140B,JTK12,PDGFR,PDGFR1,
Gene summaryThis gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq]
LocationChromosome: 5   Locus: 5q31-q32
Gene position149535422 - 149493402  Map Viewer
Gene orientationminus
Gene size42021 bp
Gene sequence
OMIM ID173410