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Gene information for ZAK (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID51776
Official gene symbolZAK
Full namesterile alpha motif and leucine zipper containing kinase AZK
Aliases,AZK,MLK7,MLT,MLTK,MRK,mlklak,pk,
Gene summaryThis gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]
LocationChromosome: 2   Locus: 2q24.2
Gene position173940565 - 174132737  Map Viewer
Gene orientationplus
Gene size192173 bp
Gene sequence
OMIM ID609479