Entrez gene ID | | 51776 |
Official gene symbol | | ZAK |
Full name | | sterile alpha motif and leucine zipper containing kinase AZK |
Aliases | | ,AZK,MLK7,MLT,MLTK,MRK,mlklak,pk, |
Gene summary | | This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq] |
Location | | Chromosome: 2 Locus: 2q24.2 |
Gene position | | 173940565 - 174132737 Map Viewer |
Gene orientation | | plus |
Gene size | | 192173 bp |
Gene sequence |
| |
OMIM ID | | 609479 |
|