Entrez gene ID | | 5208 |
Official gene symbol | | PFKFB2 |
Full name | | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 |
Aliases | | ,DKFZp781D2217,MGC138308,MGC138310,PFK-2/FBPase-2, |
Gene summary | | The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq] |
Location | | Chromosome: 1 Locus: 1q31 |
Gene position | | 207226620 - 207254368 Map Viewer |
Gene orientation | | plus |
Gene size | | 27749 bp |
Gene sequence |
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OMIM ID | | 171835 |
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