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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PITX2 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 5308 Official gene symbol PITX2 Full name paired-like homeodomain 2 Aliases ,ARP1,Brx1,IDG2,IGDS,IGDS2,IHG2,IRID2,MGC111022,MGC20144,Otlx2,PTX2,RGS,RIEG,RIEG1,RS, Gene summary This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq] Location Chromosome: 4   Locus: 4q25-q27 Gene position 111558508 - 111538579  Map Viewer Gene orientation minus Gene size 19930 bp Gene sequence >PITX2:complement(36086300..36106229):Length=19930 TGGGAGTCCGTGCTCCTGCTCCTCGGTTGGCTCCTAAGTGCCCCGCCAGGTCCCCTCTCC TTTCGCTCTCCCGGCTCCGGCTCCCGACTCTTCGGCCCGCTGGCATCTGCTTCCCTCCCC TGCCTCGTTTCTCGTCGCCCCTGCTCGCTCCCCCCGGCGCTCGCCCGGGCGCTGTGCTCG CTCCTGGATCGCCAGCCGCGCAGCCGGGCTCGGCCGGCCGCCCGCGCGCCACTGTGCAGT GGAGTTTGGTGGAATCTCTGCTGACGTCACGTCACTCCCCACACGGAGTAGGAGCAGAGG GAAGAGAGAGGGATGAGAGGGAGGGAGAGGAGAGAGAGTGCGAGACCGAGCGAGAAAGCT GGAGAGGAGCAGAAAGAAACTGCCAGTGGCGGCTAGATTTCGGAGGCCCCAGTGCACCCG TGGACTCCTTCGGAACTTGGCACCCTCAGGAGCCCTGCAGTCCTCTCAGGCCCGGCTTTC GGGCGCTTGCCGTGCAGCCGGAGGCTCGGCTCGCTGGAAATCGCCCCGGGAAGCAGTGGG ACGCGGAGACAGCAGCTCTCTCCCGGTAGCCGGTAAGTGGAGGCCATCTATCCCGCAGGG ATGTGAGATAATGCGAGTCTGGAAATTTGTTCCACTTCGGAGAATCTTCACCGTAGGTGA TTTGTGGCTTTTGGGGCTAAGTTTCGCCCAAGGTAACGCAGTCGGCAAACAGACCTTGCA AAGCCCTGTTCCTTTCGTCCCCCGCCACAGACACTAACAATCTACAGGGTGCTGAAGTCG AGAGGGAAGCCAGACCGTGGCTGGCATTTAAAACGAGGTATCTTCCCTTAAATCTCGGTG CCAACACTGCAGGAACAAATCCTCGGGCCAAGGATTAGCATTCTCAAGATAAAGGGCTGG GTACAAAGTTTCAGCTACTGGAAGATTAGCCCCCTTCCCATTGTTATCCATTGGGAAAAA AAAGAAAAGAAAAAGATTCCATCTTAACTGGCAGTTAGTGACCTCTCAGGCCCAAGCGAA TTACCTGGGAGCCAGGCCTGGATGCCAAGCTCTCACCATTTCTTTGGATTGTAACTCCTT TAAATTGATCACCAGTCAACTCCAATCTGGCACTTCAGGAGATACACTTTAAATGGATGC AGAGAATTATTTTCCAGCTGGAGATTAAGAAAAAAATTTTCGATTCTAAACCTCCGAAAT ATGTTCCTCTTTTCCAGTTTAACCACTTTACTTTCTTAAGCAATTTAGAAATCAAACTAT CATAAGGTGGTGTGATTTTTTTTTACTCTTTTGTGTGAGTATTGTCTTACTAAACTAAAC GGAAAAAACTTTTACCATTATAAATGTAAATATCAGAATTCATACATTCTAAAATATTTT TATGAAAAATTAATCTGATTTAAAGAAATTTCCTTGCATTTGTTTTAGTCTATCAATCAA AACTAAAGATGCTTTTATCACACAAAATATCATTTTGGCAGAAATCCATCTAAAATTCAA ATACCAATAATATCAAGAAAACAAAGCACATAAGCAAAATAAATTGAAGATTTTTGTTGA TGTAACATGAGCATACAACATTTCAATAACCAAACTTTCCCTAAAAAATTAAATAGCCAC TTCATTTGTGGAATGTTTTACTTTAACTCAGCAAAATTACACTTAAATTATTTAGGTGCT TTGTTCCTTAAGTTAAGCGTGTTTGTCTTCAAATGTTCCTAAAGCACTTATATTAATTGG TTGTAAAGAACGCATACACATGGTAAAATACAGAACTGAACTGAGCAGTATTTTAATTTC CTTAAATAATTACTTACTACAAATTAATTTACTGGCTAATTTCACAATTTAGTTCATTTA AAACACATGTTCCTGTGCTGTTTATTTTTAAACTTTCCATTAAAGATTTTGTTATGGGGT AACAAAGTGTATGAAAAGGGGGGAAATGTGAAAGGATCTGGGATTATTCGAACTGTATTT TTCCTGCACTTTCAGTCTTGCGGTAGTCATCAGAAATTATTTTTTAGCAAATTGTTTTAT TTCTTAGGGCTTGCCTGCCTGCTTTGCCATGGTTCCTCGTCCTCCGTTAGCCGTGTAGTG CTTTTTGTGTGCTCACAATATAAAACCCAAGTTGGCCAAAACAAGAGTCCTTGGCATATA CATTCCAACTAGAACATGAACTTTGGGGGTGAGAACTACCTCCCATCAGGAAAAGTCTCC CATCTCAATTTGTGAGATTAGCCATTGAAGCCAGTTCCGAAGTCTGGCAGCCAAATTTCT CACAGAAGACTTGTCTTGATAGGGCAAGTTTAAGGATCAGCAGGCGGGAATTGGAGGTCT CTTTTTAAAAAATTATCTTCCCCAGTTATTTAGACTCAGTTCTTCTAGTAGGCCTGGTCA TTAAATGAAGCATAAAAATGCAAGTCTCAAGGCTCATTTTGACTGCAAAATAAATCTCCA AGTCACAAGGACATGTAGGAGTGAGCTAAGGAACACGCCTTGACCTTCTTTTCAGTCCTT AGAGTGGAGCTCTATGAGTTCTTGAAGATTTGTTTTGTATTGCTTTGTTTGGTCTTCAGC ACTGAAGCACGGGGAAGTGGGGGGAAGAATGTGTAATAATTGACTGACTTTACACCAAGC AACGCAATCTTTTTCTTTTGTATATTTCATTCTTTAAAAAAAATAAATAAATAAAAACTA TTTGCAGTTACCATCTGCAGTGCTCCGGCTACCAGCTAATAATGCAGCCAGTTCAGACAT ATAAAAAAAAAAGATTATCGAAATGATGATGACATGCAAATTTCCTCCGAAATTATCATA AGTAAACATTTGAAGTCTGGACTAATAAAATCCCATCTGTGTTACTTCATATCGAGTTAG TAGAAAGCTGTGATAATGAATTTTGTAATATCTCACGAACAGACATCTCAATCAGGGACT AATCCTGTGATTTTACTGCAGAATCACTAAATCTGGAGCCGCCAAACTGCTACTTCTGGG CCCACGGGCCCACAAGGATCGAATCGGCAGAGTCCCCGCCCGCGTTCTCGCTAGCGGGTG GGGGAACCGCCTGGCCGTCCCCACCCTGGATCCCCACGCCACAGCGCCGGGCAGCCCCTC CTGTAGGCAGCGACCTTGGCCAGAGGCTCCCCAGGGCCCAGCTCCCTTCAGGAGAGGCCG AGACGCAGGGAAACGGTACTCAGGCCAGAGGCAGGCCCGCAGCTCCCTGCCCCGCCTCTG TGCCTCCGCCAACCCGACAACGCTTGCTCCCACCCCGATCCCCGCACCCGCGCGAAGTGG GCCCTCCGGTCGTCGGCGTACCCTGGTTAGCGTGGAGAGAGGCAGGCGCTGAGATCGAAG GGGCCTAGGGAGCCCTGGACCTTCTTTTCTTGTCTTTAAAGCAACCGCGGCTCTTCTACC CACCCGGTGGAGCCCCTCGAGACCCACCTCTCCCGGCTTGCCTGTGGCAGAGAAGGGGGA GCGCGTTAAATGCTTGGCTCGCTGCGTTGTGGTTGAAAACGTGAAAAAGATTTGGCTCGC CCGGGAGAGAAAGGGGGAGAACTGGGTAGCAGTTATACCAGAGCTATTTCTCCGTCCTTG GCGGGCAGTAAACCCTCCAAGAACGTTTGCCCTGCTCTCCTCAGTCTCGCTCAGTCCACC CAGTGTCTCTCCTCTGCGATCTTAAATCATACTTTAGGGTAATTATTTGTAGTAAGTAAA TAAATGGCCGGGTTAGTATCTCTAGGAGAAAGTGTGGCTAAATATGGAAAAGTGGCTCCT GATGGATGAGAGGCCCGAACTCAGCTCGCTCCTGAAACACCCTAGGCCAAGAGCCCGTTC GTTTCAGAATTACAGAAAACCGAGGGAAACTGCTGTCTAGGACAGGGGCACGTTGGCGCT GATGTTCTACAAATGTTTACCGAGCTCCAACTAATGGACAAGCACTGAAGGGTGGTCTTT GCATACAGCTTCCCAAAGAGAAAAGTCCTCTCCACCCACCCACTCCCGCTGCCATTGCGT TCAGATGAGTTCTTAACCCCGGCACCGAGATTCTTGAAAGTAGGTCCACAGCCTCCCCAG CACACTGTGGCTTTATAGTCCTCTAACCTCTGGGCACTTTTGCGGCAACTCTGGAGGGAG ATCCCCTCTTGATAAATAAATGTCCTGGGCCCGAGGCTAGGCTGGAGATGCTGCTGCACA GCCAGAGGCTGTCAGGTCGGAAAAACACGCCTGAAGCCTAGCACACAGTAGGCGCCTAAC AGCTAGTGTAACGTAGTCTCATCTGAGCCCTGCTCACTCGACGGCCGCCGCTTCTTACAG CCTTCCTTCTCTTCTGTTTTGCAGATAACGGGGAATGGAGACCAACTGCCGCAAACTGGT GTCGGCGTGTGTGCAATTAGGTAAGAACCCCCTTCTCCTGCCCGGGTCATCGGACGGGAG GCCGCGCCACGTGAGGGCGGCAAGAGGGCACTGGCCCTGCGGCGAGGCCCCAGCGAGGGG CGCTTCCCCGAGGGGCCAGCCTGGGCAGGAAGGAAATCAGAACCAAATCGCCAGTGGCCT CTCCCTGTGGCGGGGCGGTGGACTAGGAAGCAGCGGCGCGCTGTGTACCGAAGCCCCCCA GCCTACTCCTCCCGGCTGGAACCGCCGGCAACCGGGGAGGCGCAGAAAGAGTACGCCATC CTGCCCCGGGTTGCCAGAGGGTCCGGGGGACGGGGATGCCGTCAGCTCTTTCCTCTAACT GGGTCTTTGCTCTTTGTCCCTCTTTCTCCTCCGGCCTGCCTCGCCCCTCCCCCTCCTCCC GTCCCCGGCTCCTTTCGGCCGCGGTCCGGGACGCCTCTCTCCGCACGTGGGGCGGGCGCG CGCGTGGCCCAGGCGTGCAGCCGGCGGCCGTTGAATGTCTCTTCTCCAAAGACTCCGAAA TCAAAAAGGTCGAGTTCACGGACTCTCCTGAGAGCCGAAAAGAGGCAGCCAGCAGCAAGT TCTTCCCGCGGCAGCATCCTGGCGCCAATGGTAAGGCCGGGAGGGAAGCGCAGGCCGCGC GCTGGGCACCCGCCTCCGGGACTCTGGGCCTCGGGCGAAGCGCAAGAAGGCGAGGCCGCC AGACCTGACGCGCCTGCTGCTTGAACTTAGACACTCCGCCTCTGGGTGGGACGGGAAGCA GCCGTCCCAGGGACGTTAATTCCTTTCCCCAAATTATACTGCACTCCTGAGACCCAACAC CTCTCTCTCCCTCTCGCTCGCTCCCTGTGGTCTGATCCCCTGCGCACGCTCCAGCAAACC TCGGCGTCTAGGCTGGCGTGGAAAAGTGGTCCAACAGCGACCTCTGTCGCTCGTTATATC CCGCTGCGCGCAGCACCACCAGGGCCCACTCAGTCACTCAGGCTCTCAGCCACGCCCCAC CCAGACTTGTGGGTGCGCGGTTCATCGCGGGAGGCAAGCAAGGGAAACTTGAGTTGGCGA AGGTTTGCTTTGGCTGGTTGGGGGAGGGGCGGGGGGCCGACAACATCCCTGAAGAGCTGG AGGGCAGCCACTGTGCTTAGCAGCCCAGGGTAGAATGGAGGTTTGCCCCTGTCGACGCGA ACCTGCCTGAAGTACTGGTTGCCAGGCCTTGGGTTTTGGCGATGTCGTTGCTTGATTGGC TGGTTTCACTCTGGAGGAATCGAGGGACATTGCCAGAGGAGGTCTACAGGCTTATGTAAA AAGTTAAAAAGTCTCCAACCTACGCCACAGGCCTTTCCTGAATTGAAACTTGTTCTATGG GGCGGAGGGGGGGGTGTAAGGGATGGAGGAGGGAAGATGCCTTTCTTTTCAAATACATGG AAAAAAACCCCTCAAATTTACTGTTCCTCTATTTTCCTGGCTCCGTAGTAAATAAGTGCC TAGCCTTAGGAGGCTATTGACCTTTGATAATGTGAGCAGATAAAGCCCCCCCCCCCCCAC AGCCCTCGGCCCCTAACCCCCTCTTTCCGGATTAAAGTGTAAGAATACAAATGTAATATG GGATGGAGGGGGGCGATTTGGGACCCCGGTCAAAAAAACAAACCGTATTACTAAGAAGAA AACAAAGGTCTTGCATTGGAGTTTCCCCGTGAATCTGAGAGAAAATGATCATTTGTTGAA ATGAAGCGTCTAAAGCGATCCAGTGCTTCACGCCCGGACACTGCACTACACCGCCAGTCG CCCTGCTGGGCCAGTTAAACGCTCACTTGTCCGGGATTAACCCCATGGGGTTAAATGGGG GCAATGCAGAGATAACGTCGCGTGATTTCTGTCATTTAGATTGTGTTAAATTCTTCTTCT GTTTGATAATCGGTAGTAAAAATAAATTATTAGACCGTAGTATGTTTGGGATATGGTTAA AAATCAAGAGCAGCGATGACTTCTGGGGAGAATGCTTTGCGCGGGCTCAGCCCTGGCTCC GGCCAGACTAGAGGAGCTCCCCAATCTCGCTTCGCGCGGGGCGGGCTCGCAGTCGCCAAG CCGAGGCTGACATTTCTTATTGTGCTGGGAGCCAGAGAGACGCAAAATGTCTCCTTCCCC CAGTCCCTACCCCAGGTTTCCTAGACATGGGGAATGCATTCTGAGGACAGGTGGAGAAGC CTACGGTAGGATGGGGTCCTCGTAGGTGAGCAGGAAACGGCTAAGAGCAGAGGAGTTCTG CTTGCGCCAGTCACAAGCCGCGCAGGCGCCCCTGGTCGTTCGCTTTTGATAACTAGCACA TAAAGAACTAGAAATAATGAATGATTGCTTTCTTAACCATTACTTTCAGGCCCGCATTGT TTTAGTGCACGTGAAAGGCTCTTCCCCTACACTCAATATGTCTTTTTCTACTTTTTGACC GAAAAGAAAAATTGCTGCCTAAACACGTTTAATGCCATTAATTAAGAAAAGGCATGTAAT GGGAAGAAATGCTGAAAATCTTGATTTAATTGGCTTTTAAGGAACTAGTAGACGACAAAA AAAAATCACACGAGTGGGCAAAGCTATAGCACTGCTGAAGGATAGAGCACCTATCCTTCC CTGATTTTAAGTTAACTTATGGAATATCCAAAGTCCTGGCCACAGCCTGCTTGTAAAACA AAAGGATTTATTTCTTGTGTTTTTTTAAAGTTTTTCTTTGCTTTTAAAGAGAAAAAAAGT TCACAATGACATATGACTTCTTCAAAAGGCCGTGATAGTCTATTACGCTACCCTCTCCGC CTCTGCCCCCAACGCCGCCCAAAAATACCATGTCCTCGTTAAAGACTAAACGTTCTGTAT AGGCAGAGTCCACCTCTAAGCAGTCCAGGCTCTGCCTTCCTTCCCTAGTGAGTCCCATTC TCCTTGGTATCCATTGGGCGGATGCCCAGCCTGGATAGAACCCCGAAACGGGGGTAGCAC GAGAGCGACTGGAGACCCCTAAAAGCCAGAGGTTTGAGAGAGGGTGGACGCAGCTAGCAG AAGATGGTGTAGAAGCCAGCTGAGAACGACCCCCTAGAGCAAAGAGACCTTTCTTTGGCT TTTCTTGCTTTGGGGGTCCTGAAAGGAACTCATAAAATGGTCTTCACCCTCAGGAGGAGG ACGGACTGACCCTCCTCTGTCACTGGCTTAAAAAGTTTCAGGGCGGCGGCTCTGGGTTCC GTGCTGAAATCGGACTGCACTGCAGCCCCTTTGGACCTGACGCCTGGCTTTGCGTCCCGA CAAGGGGCGGGTACTTCCCCCGGCCTCCCCCAGGAACGCATTAATTGTTAAATAGCTTTG GCCCAGTGGATGGGCTGAAAGTGTTCGACCCAAGTCGCTGGTGTGCACAGACTTCCTCCC TCTGGGAGGTGGGCTCCATGGCCCGTTGTGGCACCCCCAGCCGCGACACACACCTTCACA CGCGGCAGCAGCTCGGTCCCAACCTTCTTCGAAGGACCTGGGTTAACCCTGGCGGCCTTG GCGGCCGCAGACCCCTCTCCGCCGCCCCGCCCCCGCGCCTCTCATTCAATCAGCGAATGT TTGCGGAGCATATACTACGTGGACTCCTAATGTACCCCCTGAAAGCAAATAATACAGTTT TCCTCGCCGTCATGAAGGGATTTTAATCCTAACATGGACACCAGCGAGATCAGCCCAGAC CGTCTCTAGCAAAACGCAAAATGGTGGTGCGTGGGGTGGTGACCAAGGTCCTGAGCCTTG TCAGAAAGAAGGGGATGTGTAGAGAAAGGTGGAGAACTCTAGCTGTGGCTAGCGCGGAAG GGACAGGTGCTTGCCGAAGGGGGCATGAGGCTTGAGGAAAAAGCAACGAAATAGGGGTAA GGAGAGTTTTCCATTTTCTTTCCTCCGCCCGACCTCCGCCATCCCATTCTCCCCTCCCCT CCCCCACCCCCCGCGCCAATCAAATCTGCAGCTCACTTGAAAGGTGCCCCGCCGCGTTGT GGTTTTTCACCCCCAGGGGAAATTGTACCAGTTGTCCGAAAGTAGTCAGTCCCTGCGGAT CCCTGCCCGCAAAAGTGGTCTTCACAGGTCGCGTTCCTCGCTGCTGACTCGGTACACAAA GTTTCTTAAGGCTGGTTCGGCTGTTATTCCTCACCGCCCGCTGCTAATATATGCAGCAGT TGTTAGAGCGGCTCGGGGGAAAAGGAAATGTATAACGAAAGCTTATTCGTGAGCAGGAAT ATACTAATGGAACAATCTGATGTCTTCTTAATCCTATGTAAAAAGCTTTGTCGTCTTCCT AATATTGACTGAATGGGTAATTAATGGCTCTTCATCTAGGCGAATACCCTGTAATCCAAG ATAGGCAAAAGACAACAAGCCCAAGGTAGAAGACAAAAGGCCCAACTGCAGCGGCGTTTG CCCGCCTCCTACCCCCCAGGGTCTCTGACTAGGAAAGTTTTCTCTCAGAGGAGAAAAAGG CAGGAGTGGGAGAATATATACCTATCATTTCGGGGCTAGACTTCACCGCAGCACCTGACC ACCCAGCTCAGTTTTCTGTTACTCTGTCTTTCCACCTCCAGTCCTTCTCCCTGCATTTTT TTTTCTTCTTAACTCCTCTAGGATGACCTCCTACCACCACCGCCATTATGGTCCTAATAA CCTTTCCCCCTAAACCCCACATCTTTCACTTCAGCAACCAATGAGGCTGTTTTCTGATCC AGGAGGAGATTCTTTTCTTTTAGAACCCAATGCGTAGAGTCTTTGAGAACTAAAGTAGTT GGTAGGGGAGGAAGAAATTAATAGAAAGGGAGAGAGCATACAGAATTGTGTGTGTATGTT AAAGAGCGACCAGGAATGACAGAGTCAACTTCTTTGTGAGGATCTGACGGGAAGAGTGTC CAAGACTCTACCAGCATGTTTTTAACAGGCTGACATTTTAATTTAAACCTTTAGAAGTAA TATATTACTTGGGTTACTACAATGAGGTGGGTTCCTTTTTTTTTGTCAGCTGACAGCTTT TAAAATATTATTTCGCTAGGGAAATAAAAGCTTCATCTCAGATTATAGGTGGGTATTTTT GGATTTAGGTGATTTATGGTCACCATGACAACTAATGCTGAATGTTAGCTACCAGCATGT CTGGGAGAGAGAAAACAGAAAGAAGGGAGAGCAAAAGAAATAGAAAAGGGAGATGGACAT AAGCTGGAGAGGGAAGAAAAGAGAAAAAGAGGAAGACAGATGAGTGTTTAATCCAACTGT TGTTTAAAAAAGTGGCGGGGGGGTGGGACTTCATTTAGCCCCTTGCCACTTCCTTCTTTC CTGACCTGGATATCTATGCTCAATTTCATATTCCACCCTTCCTTCCCCTTCTCCAAACAC ATGTGCTATACCATTCTCCTTATTTTACTTAGTTCGGCAAGTAGTTGCTTTCTGGAGACT CAGTGACACCTAGGAAAACTGTGGCAGTAACATGCAAATGTGAGGAAGCATTAACAGCAT GTTCGTTGAGTGATTTTAGCAAATGCCCCCTCCTCTAATCTCTTTCTCTTCTCTTCCCCA GGCCACTGTGAGGTGGTAACTCCCACTGCCATCTGAACACTGTTCCCCCAGGTAGTTACC CCAAATCTCAAATGGTTGAGCAGCTAGAGCTGTGGGTTGGAAAAATGGGTACCATTTGCA GGGACCCAGAGAGGGTGGCTGTTGCTCAATATATCTACAGACTTCCAATTCAGAAAATAA TCTTCCCCTTTTGACAAGCCAGAGCTTTTTAAATTCCATTTAGGAAATGGGGAAAAGGAC AGCTACAGTGAAGCTTTTAATTTCTGGGTTATTTGGTTCCATAGCTATGAGGGGTGGTGG GTAGTGGACTGTTTTCAGCTTGGTTTGTATGCAGAGAAAAGCCAGATATTGGAGGGGGTG GGGCACTTCTCGGGCAGGATGCAAGGTCTCCATCTGACCTCTGCGCCTTACCAGGAGCTC ACACACTCACGCCCATCACGTGGCTCCAAGCTGAGTCCAGGCGGGCCTCGTCCTTGAGCT AGCTTGGGCAGGGCAGGACTCCCACCCGTCTAAGGCCTAACAGCTCAGGGAGATGTCTAA TTAAGCCATCTTCTGGGTGAACTCTGAAGACAGACTCTTTCCAAAAGTCAGAGATCACTT GGTTGAGTCCCAGGCCAGATTGATACGGAGAGTTTGGCGGCACAGCCCAACCGCTCACTG CCATGGCCAGAGGGACTTTGCACAACTAACACTGAAGAGTGTGAAATTAAATAAGACTTT AAGACTGGTAATCGGTGGCAAATACCAGCACAAAACACGGCTGACCCCATGTCACACATT TCCCTCCTCTAGGGTCTTTCTTTGAAAGAATAAGCAAGAAACCCCAATCGAGACAACCCC TGATGTCTCCCAGACTCAAAACCTCACGCCGGCACTGGGCTTTCCTTCTTTGCCCCACGT GAGCCATGCAGCACCTCTAGTTTCCCTACCAGGATCCCACCAATGTTCTCCGTATTGGAA ATTTCTGTGTTAGAGGCTGAACTCATAGTAATTTCTAAAACCAATTAAGAAGAACTTAGC CAGAGGTCACAGTAATGCTGGAATCACAAAATGCATAAGATTTATTTTCTTCTGGCCCCT TTCTCATCCATGCTGCCTATGCCTGTGCACCCACAAGTCTTATGTACATTAAATCTCCAA AATCAACCACCACCATGCCACAGAGTTTTCACTGGACAGTGTTTCTTAGTTCCCACCACA TACCTCCTTTTCCCCATGCAGACTTATCATGTTGGTGTCCTGCCACACAGGGGGCCTGAG AAGAATGTCACCCAATCGCCGCTGCTGTGAGTGTGTAAAGTGATTAGGAGATTAGGAGAA TGTTGAAACTCCTGCTGGAAAAATGCAAAGAAAATCCTCACTTTGAGTCAGTTGTTTACA GAGCCAGTGTGTGTGTGCGTGTGTGTGTCTGTAATATAAAATGGATGTGAATATATATAT ACAAATAGATATGGTTTTGCTTTTACTTTAATCTGAATTATCTAGATAATTGTCTTTATT CACCACTTGACTTCAATGGGTCCACACAAATTAGGACACCTTATCTTTTTAGGCATCTAG GCTGCTGCTGATCCCCAGTGCTTCCAACATCTCGCACACGTTGGCACTATGAGGAGCAGT CACGTGCCCTTGGGTTTTTCAACCACTTTGGAGGCTGATTGAGGTCCTTCATACATGTAT ATTTGTCGTGATGAAAGTTCCATCGGTAGAGTGGAGCCACCAGAGCTTTTATCAAAATTC TGTGGGTTTATGAGAGATGGGTTTAGAAATCTATATGGCTCTGTGGGGCTTCTCGGCTTT CTAAAATAAGGCATTAACACCCAAGCTTCCAAAAATATTTGCAGCTCTGGGGTTTGAATC TTGAAAAACAAGGAGTGAGGGGCTGTGTATACTAACTACAGTGGAGATTTTTTTCATTCT TTAATGTGATGGAGTCCCTTCATGAAATGAAGCTTTAAGGGGCATGGTATTGTGGGGACC ACAGCTATTCTGAGGTTTAAAAGAAGAAACTGGAATATGATTAGTAAACACATTCAGCAG AAAAGAGCTGGATTCTTATTGACTTAGTTATAGGTCATCGGCTGGCAGTGCAATGGGAGG AAATATTTACTTTACACATATACTTTATGATCTTGGGGGAATTAGAGGAAATTCAATAAG AAAACGGCTAGAAACATTTAAAACCCTTATTTAAAAGACTTAAGCAAATTAGAGTCTTAT CAGATTAAAAACCACTACAAATGTAAGAGCATTGTCTTCAGTGAAACGCTGTGGGGTCTG AGAAGGAGATTCTCCGCCAAATCTCCGGGATAAAATGCGTCATTTAAGCACCAGATAATG AGCAGAATGTAAATTAATTTAACCTTCTTTACCAACAGGCTGCTAGTGTAATGTGTATAA TTTAGTGATAAGATTGCAGGACCTAATATAGCTGGATGTATGAGCCTCAGCTAATGCAGA CCTGTCACATGAGGATGTGTTTTACTCTGAGCAGGTGTCTGTATGTGTGGAATGGGGTAA AGTGGAATAAAAGGTTAAAAGCAGAAATGCTGATTTAAAGCTTACTATGAAGAAATTCCT CCCTTGCAGCTAAATTATTCTTAAAGTGGGATGATACTGGTGAAGAAAGACTGAAAAACA ATTCTCATGTGCGTCTTTGGACTGCAAGTTTAAAATGGGGAGGAGTTGCAGATAGGGTTT GGGGGTGGTCAGGGCAAAGGAGAGACACATAAGTTGCAAATATATTTGTAGTCTGCTTCA TCCACTTTGTTCCACATCGAATAAGTTTCCCAATCTTGTGAACAAGGACAAGGAGGGAGT GTTTTAAAGATACTTCATGCTGGCATTGCAAATCATTGACTGTAATGTCAAACAAATACA CATTCAGAGATGATAACACTAACTCCATAGTAAAACAATCGCCCATGCAGAAACCCAGAG GAGATTAGTTTGTCCTCTCCAGCTGACCTATGCTGGGGGACAAAAGGACTTTCAAAAATT ATTTTGAATATGTTTGGATTTCTTTCTTTAATTTCTTTGGAAATTAAATTTGCTTGGAAA CAGTGCTATAAAGAGTTGATGTCTCCAAAGGTGATTTTTTTTGTTTTATATAAATAAGGT TTTGCTTTTGCTAGTTGAGCGCAGTTCTAGGCTTTTCGCCCTTAGCTCACACACACCCCT TCTGCCTGCTTGGACTTTAATGGCTCAAGACAGCCTTGAGCTCACTGGGAAAAGAAAATG ACTGTTAAAAATTATCCTTGAAATTGGTTATTTGGCAACATTCTTAATTGTATGGAAATT CATTAAGGCATATTTCATATATAATTAGCTCAAGGTTGTTGATTCTACAGGCTTTATGGA TTTAAATCTGATTGATAATAAAGTAAACAAGAGAGTCGAATTTAAAGCGTGGCTCTCTCG GGTTAGGACGAGCTTAATACAGTGTACAAGGAATTTGAAAGATCTAGGATATGTGTCTTA ATCAACGTTAAGTAGAATGGATAAGCTTTCAGCATTTTGAAAACGCTGGGTTAGGGTTTC TCTTCTATTGTGTGTTTTCTGTCTGGGGACTAATAAGCATCACAGAGAACGTGATCTGAG GCGACTTTTTATTCTTGTATAAATCCAGAGTGAACCACCAAACAGTTGTTCGTTTAAAGT CAAGGTAATTTTCTTTTGACGGGTCCATTTGCTTCTCGATTTCTAATTTATTAGCCTGCC TTTTCAGGGCTCTGTCTTCTTTGCAATTAAAGCTTCTTCAGATTAGCGCAGCATTCACTT GACAGGCTGTTTGGAAAATTTAAGATCGGAGAGGTGATTTGTTGCTGTTTTTCAAATTTT CTAGTTTTAAGTAACGTGTCTCCTTTTTATATGGGGTGGGGGATTGGAAATGGATGTAGT GAGACACAAAGAGTGGGTGTCTTGTTGATCCTTGTACCTTTCTCTTCTTGACCATTCCAC TCTCTTCTCCCAAGCCTTCGACTCCTAGCCTCATCTCTTCACCTTTGGGTTCGTACTAAA AGCCGGATCGCCTTGGGCTGGGCAGGAGCTGAATTCCCGGGAGCTTGCCTGTGTAGACCC AGTGCGCACGGCGAGGCAGTAGCCCGGCCCCGCACTGCTGATAGGTGCAGGCAGGACAGT CCCTCCACCGCGGCTCGGGGCGTCCTGATTGGTGCGGAGCCACGTCAGTCGCACCCGGAG AAGGGTCTGGGAGGAGGCGGAGGCGGAGAGGGCTGGGGAGGGCCGCGGCGGAGTGACGTC TCGGCACCAGGAAGCCCGCCTCTGGTTTTAAGATGTTAGGCCAACAGGGAAGCGCGGAGC CGCAGATCTGGTCCGTCGCTCGCCTGGGTGCCTGGAGCTGAGCTGCGGCAAGGCCCGGCT CCTGTTCGACCGCCCGAGGGGTGTGCGTGTGCGCGTTGCGGAGGGTGCGCTCAGAGGGCC GCGTCGTGGCTGCAGCGGCTGCTGCCGCCGCAGGGGATCTAATATCACCTACCTGTCCCT GTCACTCTTGACACTTCTCTGTCAGGGCTGCCGCGTGGGGGGGGGGCGGGCAGAGCGCGG TCGGCGTTAGCTTTCCTTATTGGAGGGGTTCTTGGGGGAGGGAGGGAGAGAAGAAGGGGG TCTTTGCCCACTCTTGTTTCGCTTTGGAGCTTGGAAGCCTGCTCCCTAAAGACGCTCTGA GTGGTGCCCTTCTGCCCACATCCCATGTCTTCGTTTGCCCGCTGACTTTCCGTCTCCGGA CTTTTTCGCTTGAGCCTTCCGGAGGAGACGGGGGCAGCTTGGCTTGAGAACTCGGCGGGG GTTGCGTCCCCTGGCTCTCCCCGCAGCGGGGAAACTCCGCGCCTAGAGCGCGACCCGGAG CGGGCAGCGGCGGCTACGGGGGCTCGGCGGGGCAGTAGCCAAGGACTAGTAGAGCGTCGC GCTCCCTCGTCCATGAACTGCATGAAAGGCCCGCTTCACTTGGAGCACCGAGCAGCGGGG ACCAAGCTGTCGGCCGTCTCCTCATCTTCCTGTCACCATCCCCAGCCGTTAGCCATGGCT TCGGTTCTGGCTCCCGGTCAGCCCCGGTCGCTGGACTCCTCCAAGCACAGGCTGGAGGTG CACACCATCTCCGACACCTCCAGCCCGGAGGCCGCAGGTAAGGCGCCGCGCCGCCCTGCA GACATTCCCGCTCAGCTGCTCTGCGCCACCCGCTCCCTCTCGCCCCAAGGAAGTCAGCCC CTCCGGGGGGAGGCGTGGTGGGAGTGGTCGTTCGCCTGGCTCCCCGCAGAACTTCCGGGA GCCGGAATTTTGACTACCCCGCATCCCTTTAGTTCTCCCTCGACCGGCCCGGCTCCTGGG GCGCTAAGGGCGCGAGCAATTCTGCCGCCCTCTCTATTCGTACCCTGGCCTCCCTTCTGT TTCCTGGGTCACAAAAATCCCAGCATCTTGATTCGAGGACCTTCAGAGGCCGCCGACCTC TGTCCCTGTTTTCCTCTCGGCTTTCAGCTCCCGAGGAGCTCCACTCGTTAGGAAATTGCC TGAAACCACTCAGAAATGCCCTTCGCGAAGAGGCATTTTTTTTTTTTTTTTGGGAAAGGG CCGGCGAACTTCGGTGCCCAACCGAATCCCCACATCTTTTCCTAGCCTTCCCAAACCGCA TGGAAATCTGAGCTTTCTGCGAGGGGGAGGGGGGTCTGTAAACCACGCGCGTGTGCGCGT CCCAGGAGATTTGGTGTGTCTGCGCAGAGGTGTATAAATATACTTGAAAGCACAGGCTAT AAAAGTGAATGTGCCGCTGCAGTGAGATAAACATGTAAATAAAACGTGCGGCGCTGGGGG AGGGGAGGAAATGGGGCGCGGACACCCACACTTGCGCCTGCACACCCCACAGGCGCAGCG CTCCTCGCGGCCCGGAGCCGCCGCGCGCACCCTCCTCCGGCGCCAGGCAGCCCAGCTCTT CCACGGCTTCTGCCGCCGGTCCAGTTGGCGTCCGCGTTGCAGGTGGGCATGCTGACGGGA AAGTGTGTGTGTTTCGTTTTCAGAGAAAGATAAAAGCCAGCAGGGGAAGAATGAGGACGT GGGCGCCGAGGACCCGTCTAAGAAGAAGCGGCAAAGGCGGCAGCGGACTCACTTTACCAG CCAGCAGCTCCAGGAGCTGGAGGCCACTTTCCAGAGGAACCGCTACCCGGACATGTCCAC ACGCGAAGAAATCGCTGTGTGGACCAACCTTACGGAAGCCCGAGTCCGGGTAGGAGCCAG CACGGAGTCTGGGAGGGATGGGGGGAGGATGTTGTGGAGGTACAGGCCAAGTAGACCAGG AGAGAATGTGGAAGGCAGCGCCGCCTGGGAGGGCGCCGGTGGGGCGCAGCTTTGCAAAGG CAGAAGGCCTCGCGGCGGCCTGGTTGCGAGATTACAGTTCCCTCTCCGAGGCCGACAGGA CTGCCGCCCTGGCTCAGGCTCCCAGAGCGGCACCGGCTCACTGCCCCGCCATCCCGCGAT CTCACGAGCTGGGCTGCATGGGCAATCCCCTGCACAGGACATTGTGTTCCTGGCTTGCAG TTGCCAGAGCAGAGCTAATAAAATCCCTACCAGGCCAAGAGCCGCGAACAGGCTCCAACC TGTGAGCCTTTAACAAGGAAAACCCGCCAGAGACACGGAAGAGTTGGCCCTCCCTGGGAA ACCTTTGTCCCGGCCCTGGCCCAGCTTTTTCCCTCCTGGGCTCGCGCTTCTTACACCTTC TTTACGGTTGTTTCGGCCATTCAGGTCTCTCCCACACACCCTATTTCCTAGTTTTGTGAT CTCCGGGAGCAAAGTTTTAATACACAACTACTAGTCCTCTTAGAAGGAGAAAGAAAAAAA GAAGAAAGACTTTTCTGCTTGGTTTATTTATCTTCTCTCAGGAGTTGAACTCTGGAAATT GAAACTCACACCCCCTCTTCTAAATTATAATCATAGTTTTGTAAAAAGGGCTTACCTTAA CTTTGTAGCAAATCTGTACTTTATGGATTGGCAAAAATGAGCTCAAATAAATAACCCAAT AGCAACGTCCTGGTTTATGCTGGTCGGTGGAAGATTCCAAATTTGTTAGGATTCTGGAAG CAGAAAACAGAATCAAGCAAATCAAGCGGCATCCAGAGGCTTTGCTGTTAAAAAAAAAAA ATTAAGTGCTCTGGGTAGAAAAAATAAAGCCCCCGGTTAGAGCAGAGCAAACAAAAAGAA GAAAACAACGATAAAAAGAATAAAGACCAAAATGCTCTCCCAAATCAGAGGGAATGAAGA CACTCTCTGGGTGGCATTTGTGCAAGGCATGAGGCTATGCTGGTGGATAAAAGGCCGGGA AGAAGTTGAAAATGGTTTTAGTTTAACTGTCCAGAGCCAGAGCTGGGTCCTGGGCGGCGT GGTTTTGAGCAAGGTCAGTCTTTCATTAGCTCTCTTGCACATCAAGGGAACGGGCCTCTC ACGTACTCTTCTCGCCTGAGCAAAGTTTAGATGGCCTAGGGTAGAAATGGCAAGTAATTA AAGACAGAGTCTATGGGTTTTCTGGGATCCTTCGAAAACGCCCTCCCACCCCGCCCGCTA TTCCGCAGCTCCACCCTAGTGCTTTGTAGCCGCGGCGCTGGGCTCTCCTTGCAGCTGCCT CTCCTTCCAGGGCGGCTGCTTGTCGAGCCAAGTGGGAGTGAGGCGTGCTTTTTATAGCAG TCGGGTGCAAAGAGGAAGGGGGATAAAAAGGAAATCAAGAATGAAAGGAAAAAGAGAAAA AGCGGATTACACGGCTGGGCCCGGCGGAGATGTGTAATGTGAAACATCACTGGTGTCAGC TCGGATATCTCAGGCCAGGCCTCTCTCCAATACACAAAAGCCGCCGTCTGGGGCGACAGG GAGGCCCGATGTGGATTGGGATCGGGGTTGCGGCTGGGCCACCGGACACGGGTGGAAGCC GGCCGGCCTGGGTGGCCGCCTGCAAAGCCAAACGACCCGGCTGGGCCTGGCGCGCGGACA GGCCTGTGGTGGGCTTAGGGTAAAGAAGAGGCAGAGCGAAAGAAGGGGGAATCTCCAAAA CTACCCTTTCCGGGTTCCCGGAGTTTAATATGCCAAGCTCCTGGAGTTAACGAGCTGACG AAGAGGTGGTCTTTTGCTCTTTATTTGGTTGTTTTGCTAGGCGAGAAAGAGTGTTGGCGG CCTAGTCCCTGTTAAGGGAGCACGTACCAGGGGGTGGGGGACGACAGTGGAGGTCAGGGA AGGAAGGGAGGAATTGCGTGGGAGAAAGAGCGATCCTCTAGTGCCCTTCCAGCCCCTTCT CCTCATCCGTGGGTCTGTGGCTTTGGAATGGAAGCAAGTTTGCAAGGTGCCCCGGGAAGG GTTGGAAAAGCCTGCTGCCCCGCGTTTGTTTTACATTAAGTGTTTTTGGACCTGGAGAAA CGCCTGGCTGAGTGATCAAACCGTCCGCAGGTCTCCATGCGTTCGGCTGAGGTTTGTGGC GTAGCTCCGAGTCCCAGCTCGCAGGCCAGAGCAGACCAGGTCTCCTGCGCTTGGTGGAGA CCCGGGCCAGTAACTGAAAGCTGGCCCTGGTATCTTGGTGTGCAGGGCGGTGCAGTGAAG CGAGGCCAGGGTGTGTGAGTGCGCTAGCGTGTGTGTCGGGGGAAGGCGGGGGTTGGCCTC CGATGGAAGTTTTAGTAATCTGCACTGTGGCATCTGTTTGCTCCCTTGCCCCAACCGCCC CCAGGTTTGGTTCAAGAATCGTCGGGCCAAATGGAGAAAGAGGGAGCGCAACCAGCAGGC CGAGCTATGCAAGAATGGCTTCGGGCCGCAGTTCAATGGGCTCATGCAGCCCTACGACGA CATGTACCCAGGCTATTCCTACAACAACTGGGCCGCCAAGGGCCTTACATCCGCCTCCCT ATCCACCAAGAGCTTCCCCTTCTTCAACTCTATGAACGTCAACCCCCTGTCATCACAGAG CATGTTTTCCCCACCCAACTCTATCTCGTCCATGAGCATGTCGTCCAGCATGGTGCCCTC AGCAGTGACAGGCGTCCCGGGCTCCAGTCTCAACAGCCTGAATAACTTGAACAACCTGAG TAGCCCGTCGCTGAATTCCGCGGTGCCGACGCCTGCCTGTCCTTACGCGCCGCCGACTCC TCCGTATGTTTATAGGGACACGTGTAACTCGAGCCTGGCCAGCCTGAGACTGAAAGCAAA GCAGCACTCCAGCTTCGGCTACGCCAGCGTGCAGAACCCGGCCTCCAACCTGAGTGCTTG CCAGTATGCAGTGGACCGGCCCGTGTGAGCCGCACCCACAGCGCCGGGATCCTAGGACCT TGCCGGATGGGGCAACTCCGCCCTTGAAAGACTGGGAATTATGCTAGAAGGTCGTGGGCA CTAAAGAAAGGGAGAGAAAGAGAAGCTATATAGAGAAAAGGAAACCACTGAATCAAAGAG AGAGCTCCTTTGATTTCAAAGGGATGTCCTCAGTGTCTGACATCTTTCACTACAAGTATT TCTAACAGTTGCAAGGACACATACACAAACAAATGTTTGACTGGATATGACATTTTAACA TTACTATAAGCTTGTTATTTTTTAAGTTTAGCATTGTTAACATTTAAATGACTGAAAGGA TGTATATATATCGAAATGTCAAATTAATTTTATAAAAGCAGTTGTTAGTAATATCACAAC AGTGTTTTTAAAGGTTAGGCTTTAAAATAAAGCATGTTATACAGAAGCGATTAGGATTTT TCGCTTGCGAGCAAGGGAGTGTATATACTAAATGCCACACTGTATGTTTCTAACATATTA TTATTATTATAAAAAATGTGTGAATATCAGTTTTAGAATAGTTTCTCTGGTGGATGCAAT GATGTTTCTGAAACTGCTATGTACAACCTACCCTGTGTATAACATTTCGTACAATATTAT TGTTTTACTTTTCAGCAAATATGAAACAAATGTGTTTTATTTCATGGGAGTAAAATATAC TGCATACAAA OMIM ID 601542