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Gene information for PLA2G4A (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5321
Official gene symbolPLA2G4A
Full namephospholipase A2, group IVA (cytosolic, calcium-dependent)
Aliases,MGC126350,PLA2G4,cPLA2-alpha,
Gene summaryThis gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. [provided by RefSeq]
LocationChromosome: 1   Locus: 1q25
Gene position186798032 - 186958113  Map Viewer
Gene orientationplus
Gene size160082 bp
Gene sequence
OMIM ID600522