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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PLAU (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 5328 Official gene symbol PLAU Full name plasminogen activator, urokinase Aliases ,ATF,UPA,URK,u-PA, Gene summary This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] Location Chromosome: 10   Locus: 10q24 Gene position 75670862 - 75677259  Map Viewer Gene orientation plus Gene size 6398 bp Gene sequence >PLAU:26475326..26481723:Length=6398 ATATAGAGCAGGCGCCGCGGGTCGCAGCACAGTGCGGAGACCGCAGCCCCGGAGCCCGGG CCAGGGTCCACCTGTCCCCGCAGCGCCGGCTCGCGCCCTCCTGCCGCAGCCACCGGTGAG TGCCGCGGTCCTGAGATCCCCGGGCCGGATGCGCGGCGGCCCCAGCTCCCGAGCGTCTGC CTCCCCCGCCCTGGGCTGCCCGGGCTCCCTGGGCTCCCCGGCGGCTGCACGGAGTCAAGG CGCCCCGTCCCGGGCGTCCCCCGCGGGTGCCGATCCAGGCTGCCCGGAGTCCGGAGCCCA GAGAGGAGAGAGACAGCTGGGGAGCCTGGTCACCGCGGGCATCTCCCCTGCGCTGCAGTC GCCCGCCTGGCCTGCCTTCCCGTTCCTCCGCCTCTTGCCCTGACTTCTCCTTCCTTTGCA GAGCCGCCGTCTAGCGCCCCGACCTCGCCACCATGAGAGCCCTGCTGGCGCGCCTGCTTC TCTGCGTCCTGGTCGTGAGCGACTCCAAAGTGAGTGCGCTCTTGCTTTGACTGATGCTGC CCAAGGACCTCTGATCAGCACCAGGGGAGAGGAGGGGCTGCTCAGGGAGCTGGGGTCCTC CGGATTCCATCCACAGCAGGGCCAGACTCTCCCCAGGAAATGGGACAGGGTGGCAGCGGA GGCTTGAGAACCACGGGGGTTGGCACTGGCTGGCAAGGGAGGAAGAGGCCGCCGGGACTG CCCCAGCCTGCGGGCATCTGGTAGATGAAGCTTGCTTGGGTCAATCCATTTCTCCTGGCT GGAAACCCATGGTCTTCCATTTGAGAACTAGATACGAACAGGGTGAGGCGAGAGGGAGAG GGAAGAGTGGGTTTTGGGATTGGGGCCAGTTTACCCTCACCCTGGAGTCCCTGGAGCATG GGACCTTTGATGAAGCCTCCTCCCGAATCTCTTCCAGGGCAGCAATGAACTTCATCAAGT TCCATGTGAGTATCCACCCCTACAACAGTTGGCTGCACAGACAAGTTGGGAAGGCTTCAG GGGACATCCCCTCCCTGCCCTCTGCTGCAGGGCTGCGCCACCCCTTACCACTTCCACTCC CCCTCGCTTACCCCACCTTTGTTCTCTCCAGCGAACTGTGACTGTCTAAATGGAGGAACA TGTGTGTCCAACAAGTACTTCTCCAACATTCACTGGTGCAACTGCCCAAAGAAATTCGGA GGGCAGCACTGTGAAATAGGTATGGGGATCTCCACTGCAACTGGGAGAGAAATTTGGGGA CAGGGAGGGATGGGTGGGAGGCAAGAGCAGGCAGGAGTTAGGAGCTGGAGGTAGGGTGGG TGACATCTTCATCCCTATGTGACAAGCATAAACACACACACACGCTCACGAAACAGTGGC CACACAAATGTGAGGTGGGGTTGGAAGGAGACCCTGTCCAGTCTTCTGGCAGGTCTGAAA CGACATCTTTAAAATGTCCGTTGGCAGCCGGGCATGGTGGCTCACGCTTGTAATCCCAGC ATTTTGAGAGGTCAAGGTGAGTGGATCATTTGAGGTCAGGAGTTCAAGACCAGCCTGGAC AACATGGTGTAACCCTGCCTCTACTAAAAATGCAAAAATCAGCCTGGCATGGTAGTGGAT GCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGCA GAGATCTCAGTGAGCTGAGATCACACCACTGCACTCCAACTGGGCGACAGAGCAAGACTC CATCTCAAAAAAAAAAAATAAAAGTTAGTTGGAATGTTCTTCTCTTTCTCATATTCTCTC ATCCTCCTGTCCCCTTGTAGATAAGTCAAAAACCTGCTATGAGGGGAATGGTCACTTTTA CCGAGGAAAGGCCAGCACTGACACCATGGGCCGGCCCTGCCTGCCCTGGAACTCTGCCAC TGTCCTTCAGCAAACGTACCATGCCCACAGATCTGATGCTCTTCAGCTGGGCCTGGGGAA ACATAATTACTGCAGGTGAGGTGGGGGCAACAAGGACCAAAAGCCCTCCCTACAGCTTCC CAGAAACCTTGTTACCATCCCCTTCTCCCAGAGGGCTGGCCATAGCACAAGAGAAGTGCG GCCTCTGGTTGAGTCTTCCCTGAGGGGAGGAGGCAGGGAAGGCCCTCTGGGTTGGAATGA CATCCCCTATCTTTCTGTGTTGCCAGGAACCCAGACAACCGGAGGCGACCCTGGTGCTAT GTGCAGGTGGGCCTAAAGCTGCTTGTCCAAGAGTGCATGGTGCATGACTGCGCAGATGGT GAGCATCACTGACCTGCTGATGACAGTGGGGTGGAAGGGGACAAACTTACATGTCCCCTT ATTCCATCACAGGAGGACTGAGGAGGTGGGGGGTGCCCGAGAGGGATGCTTTCTCCTACC TGCCTCCCTAAGACATCCCTCTGTTTGTCCTCCAGGAAAAAAGCCCTCCTCTCCTCCAGA AGAATTAAAATTTCAGTGTGGCCAAAAGACTCTGAGGCCCCGCTTTAAGATTATTGGGGG AGAATTCACCACCATCGAGAACCAGCCCTGGTTTGCGGCCATCTACAGGAGGCACCGGGG GGGCTCTGTCACCTACGTGTGTGGAGGCAGCCTCATCAGCCCTTGCTGGGTGATCAGCGC CACACACTGCTTCATGTACGGCCCTGGGTTTCTCCTCTTCGACTCTTCTGCCCCACCCCA AGCACATCCCTTTCTCCTTCCCAGCAAAGTGTTCCGCCTCATTTCTCCCTCATCTGCCCC TGTCCATGCAGCCCATGGCCTTGGGGACAAGTCGTGCTTTGAGGCCTCTAGGGAGGGAAG GAAGAAGTGGCAGATTTCATGGGACTAAGCTGTTTGATGGGTATCTTCTCCCACAGTGAT TACCCAAAGAAGGAGGACTACATCGTCTACCTGGGTCGCTCAAGGCTTAACTCCAACACG CAAGGGGAGATGAAGTTTGAGGTGGAAAACCTCATCCTACACAAGGACTACAGCGCTGAC ACGCTTGCTCACCACAACGACATTGGTGAGGGGGAACCCCGCGACTACTGTGGCCATAAT GGCTTGGGGAGAGTGGGACCCAGGGAGAGACTGGAGCTGAGGTTGAAGCTGCCCGGTGGG GCAGGGGTGGGGCGAGGGACCTTGAAGCCTCGATATACATGACAAAGGGAGTGGCAGGGA AGAGTTCCATGAAGTCTGAGGGGCCTGGTGCTCCTCTGGAGAGACCCTGAATTTCCCCAA CAAGTAGCCTCTTGCGAGTGGAAACAGCCCTGTGGGTATATGGCTTGGGCTGGGAAGGCC CTGTTTATATGAATTAGAAAAAGACACACCTTCCTTTGTGGGATGCAGCCTCTGTCTGTG CTAGGATATAGAACTTGGAGAATGGAGCCTTGGGATGGATTCCAGCCTAACTACCTCAGC TGGGAGTTTTTGCAGAAACGACCTGTACAGCTGTATGCAGTGGCTCTGGCCATCCAAGCC TTTTTCAACACCTGGAACAAAGCCCTTGGGGCATGGGGCAGGGGAGGTTTCCAGGTGATA AGCGACCAGCAGACCTCCCTGGATGACTGACCTAGGGATAGGCATAGCTACTTCCTCGGC ACTTGGAGGGGACAGATGGGGACCGCCTAACCAGTAGTGATCTTTCTCCTCTGACCCTCT GTCCTCCCCCAGCCTTGCTGAAGATCCGTTCCAAGGAGGGCAGGTGTGCGCAGCCATCCC GGACTATACAGACCATCTGCCTGCCCTCGATGTATAACGATCCCCAGTTTGGCACAAGCT GTGAGATCACTGGCTTTGGAAAAGAGAATTCTAGTAAGTGACAATTGCGACTGACTTAGA AGGTCCTGAGGAGTGTTTTGACCTGAAAATGAGCCCAGCGTGATCAAGGGAAGACTGCAG AGTTAGAGGTGGGAGCACTGAGGCGGTGGCAGATGGGTCCAGGGATGGATGAAGAGTGTT GTTTAGGGAGCGATGGGCTGCAAAGGTAAATAGATGGTAGGGGCTATAGGTGGAGTAAAG GCTCAGATTTGCATGGAAGAGAATAAGGGCCTTCCCTGGTAGAGATACTTTATGGTTCCC CTCTCTGGCAGACTCCCAGTGGACAGATAAATCTTGATGCAAACGCCTCCCTGTTTTCTC CACCTAGCCGACTATCTCTATCCGGAGCAGCTGAAAATGACTGTTGTGAAGCTGATTTCC CACCGGGAGTGTCAGCAGCCCCACTACTACGGCTCTGAAGTCACCACCAAAATGCTGTGT GCTGCTGACCCACAGTGGAAAACAGATTCCTGCCAGGTGAGTGTTCCAAGCATCTCTCTC CACCTCTTCCATATCTCCCCAGAGCTCCTGGGCTTGTTCCAGCCAGCTTAAGGGTGTCTC TCTCTAGCCAAAGCCCTAAGTAGCCAGAATCAGGAGCTCAGGTCTTTGAGGGTTTAAACC AGTCCTTATGTGTTTGCCAGACATTACCAAAAAAATCCCAGCTCTGCGCTAGTCACTTCA GACTGGGGGCACGAGATCCTAGAAAGAGGAAACAGTAAAAGACAATGTAACTCAGTGCCC AGGGTGTGTTGTGAACTATAAATGATCAGGTGTTCAGGAGAGGGAGGTGAGTGCCAACCT GAGGGTCAGGGAGGGGAGGCTTTAAAGGAAATGTGACTTGATAGGCATTTGAAGAGGCAG AGGGAAGAAAGGAAGGTGTTTCAGTTGAAAGATACAAAACTGAGAAGGAGGCTGGCATAT TCCGGGTGGGGAGGAGAACTAGGGTCTGGGAGTGTGGATGGAATAGTGGCAGATGACAGG GCTTTTAAAGCCAAGCAGGGGATTTTAAACTTGATGTGGTAGAAAATGGGGCTGCGTCAG GCACAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGATGGATCACTT GAGGCCAGGAGTTTGAGACCGGCCTGGCCAACATGGTGAAACCCTGTGTCTACTAAAAAT GCAAAAAAAAATTAGCCAGGTGTGGTGGTGCCTGCCTGTAATCCCAGCTAATCAGGAGGC TGAGACATGGGAATCGCTTGAGCACAGGAGGCAAGTTTGCAGTGAGCTGAGATCACGTCA TTGCACGCCAGCCTGGGCGACAGAGCGAGATTCTGTCCTCCCCCCGAAAAAAAGAAAGAA AATGGGAAGTCGCTAAGGACTTTGACTGGGAAACTCTTCCCTCTCTCTGGTATGGTTGGG TGATGGGATCAGAAATCCCCTCCTCACTTCTCTAGGGCTCATCTTTTGTATCTTTGGCGT CACAGGGAGACTCAGGGGGACCCCTCGTCTGTTCCCTCCAAGGCCGCATGACTTTGACTG GAATTGTGAGCTGGGGCCGTGGATGTGCCCTGAAGGACAAGCCAGGCGTCTACACGAGAG TCTCACACTTCTTACCCTGGATCCGCAGTCACACCAAGGAAGAGAATGGCCTGGCCCTCT GAGGGTCCCCAGGGAGGAAACGGGCACCACCCGCTTTCTTGCTGGTTGTCATTTTTGCAG TAGAGTCATCTCCATCAGCTGTAAGAAGAGACTGGGAAGATAGGCTCTGCACAGATGGAT TTGCCTGTGCCACCCACCAGGGCGAACGACAATAGCTTTACCCTCAGGCATAGGCCTGGG TGCTGGCTGCCCAGACCCCTCTGGCCAGGATGGAGGGGTGGTCCTGACTCAACATGTTAC TGACCAGCAACTTGTCTTTTTCTGGACTGAAGCCTGCAGGAGTTAAAAAGGGCAGGGCAT CTCCTGTGCATGGGTGAAGGGAGAGCCAGCTCCCCCGACGGTGGGCATTTGTGAGGCCCA TGGTTGAGAAATGAATAATTTCCCAATTAGGAAGTGTAACAGCTGAGGTCTCTTGAGGGA GCTTAGCCAATGTGGGAGCAGCGGTTTGGGGAGCAGAGACACTAACGACTTCAGGGCAGG GCTCTGATATTCCATGAATGTATCAGGAAATATATATGTGTGTGTATGTTTGCACACTTG TGTGTGGGCTGTGAGTGTAAGTGTGAGTAAGAGCTGGTGTCTGATTGTTAAGTCTAAATA TTTCCTTAAACTGTGTGGACTGTGATGCCACACAGAGTGGTCTTTCTGGAGAGGTTATAG GTCACTCCTGGGGCCTCTTGGGTCCCCCACGTGACAGTGCCTGGGAATGTATTATTCTGC AGCATGACCTGTGACCAGCACTGTCTCAGTTTCACTTTCACATAGATGTCCCTTTCTTGG CCAGTTATCCCTTCCTTTTAGCCTAGTTCATCCAATCCTCACTGGGTGGGGTGAGGACCA CTCCTGTACACTGAATATTTATATTTCACTATTTTTATTTATATTTTTGTAATTTTAAAT AAAAGTGATCAATAAAATGTGATTTTTCTGATGACAAA OMIM ID 191840