Entrez gene ID | | 5329 |
Official gene symbol | | PLAUR |
Full name | | plasminogen activator, urokinase receptor |
Aliases | | ,CD87,UPAR,URKR, |
Gene summary | | This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq] |
Location | | Chromosome: 19 Locus: 19q13 |
Gene position | | 44174502 - 44150248 Map Viewer |
Gene orientation | | minus |
Gene size | | 24255 bp |
Gene sequence |
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OMIM ID | | 173391 |
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