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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PMCH (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 5367 Official gene symbol PMCH Full name pro-melanin-concentrating hormone Aliases ,MCH, Gene summary The melanin-concentrating hormone (MCH) is a cyclic neuropeptide isolated initially from salmon pituitary gland and later from rat hypothalamus (summarized by Nahon et al., 1992 [PubMed 1572663]). In mammals, MCH perikarya are confined largely to the lateral hypothalamus and zona incerta area with extensive neuronal projections throughout the brain, including the neurohypophysis. The anatomic distribution suggests a neurotransmitter or neuromodulator role for MCH in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. MCH and 2 other putative neuropeptides, NEI and NGE, are encoded by the same precursor and appear colocalized in nerve cells and in many instances within the projections. The precursor is designated pro-melanin-concentrating hormone (PMCH).[supplied by OMIM] Location Chromosome: 12   Locus: 12q23-q24 Gene position 102591614 - 102590237  Map Viewer Gene orientation minus Gene size 1378 bp Gene sequence >PMCH:complement(64733543..64734920):Length=1378 AGCAGGCTGACAGAGAAATTTTTCATTTTCTTTCTTGTTTGACTGTATGCAAACATCAAA CTAAGAATGGCAAAAATGAATCTCTCTTCCTATATATTAATACTAACTTTTTCTTTGTTT TCTCAAGGTATTTTACTTTCAGCATCCAAGTCCATAAGAAATTTAGATGATGACATGGTA TTTAATACATTCAGGTTGGGGAAAGGCTTTCAGAAGGAAGACACTGCAGAAAAATCAGTT ATTGCTCCTTCCCTGGAACAATATAAAAATGATGAGAGCAGTTTCATGAACGAAGAGGAA AATAAAGTTTCAAAGGTAAGTGGCAATGTGACTTGTCGTTTATTTCAATGAAAATTTAAA TGATTCTTACAAATCCTCTGAAAAGTAAAACTGATACTTTTATAAACAGAAGTATATGCA AACAGTCACAATATGCATTAGGACGACTGACGATATTTCTTACATGCCAGGTAGTTCTTC CATCCCAGCAAACACCTCTTATCTGAAAGTGTTTTTTCTCCTATAAATTTGCATCTAAGG TATTTTTAAAAAGTCAAAAACAGTGCAGAGTAACTTTGAATTGATCAACAAGAATATTAT ACAATTGTATTATAGTTCCACTCCGAATACGATAGCTAAAAACCAAATCAACCTTCTCTT TACAGAACACAGGCTCCAAACATAATTTCTTAAATCATGGTCTGCCACTGAATCTGGCTA TAAAACCTTATCTTGCACTAAAAGGATCTGTAGCTTTCCCAGCTGAGAATGGAGTTCAGA ATACTGAATCAACACAAGAAAAGAGAGAAATTGGGGATGAAGAAAACTCAGCTAAATTTC CTATAGGAAGGAGAGATTTTGACAGTGAGTAGTCTTTTCAAAATTCAATTCTTACATCCT ACCACCATTAAACAGAACTCTGAGTTAAAGTGAATTTGGATGCAATCATAACAAAATCAA ATAAGACCATGGCTCAATTACACCTGCCAAAAATGTGGGATTAAATAGCAACAATTAATT ATTATCATTTTGGTTTACTCAGAATTAGTTATACTAGATCCATTCTTTTTTTCTTAATAA ATTTTGTGTGATAATTATAGTCCTTTAAACAATTTAAACTTTCTTCTTCCTTCAGTGCTC AGATGTATGCTGGGAAGAGTCTACCGACCTTGTTGGCAAGTCTGATACCTGTTGGTCCAC ATCATCTTTTCAGAAGAAAATAAAAGCATTTAATTGCCAATGGGAGGAGAAGCCCATACT GCTACTATAACTTGTGTATGTTAAATGTCTGTTTTAAAAGAAAGTAGTGTTAAGATGTAT CAGTAACTGAAATGATATGCTTTCTCTGTGCATTAAACTTTGTGAAAATTCTGCATAA OMIM ID 176795