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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for GSAP (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID54103
Official gene symbolGSAP
Full namepigeon homolog (Drosophila)
Aliases,PION,
Gene summaryAccumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD; MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1; MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP; MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]).[supplied by OMIM]
LocationChromosome: 7   Locus: 7q11.23
Gene position77045717 - 76940068  Map Viewer
Gene orientationminus
Gene size105650 bp
Gene sequence
OMIM ID613552