Entrez gene ID | | 54103 |
Official gene symbol | | GSAP |
Full name | | pigeon homolog (Drosophila) |
Aliases | | ,PION, |
Gene summary | | Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD; MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1; MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP; MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]).[supplied by OMIM] |
Location | | Chromosome: 7 Locus: 7q11.23 |
Gene position | | 77045717 - 76940068 Map Viewer |
Gene orientation | | minus |
Gene size | | 105650 bp |
Gene sequence |
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OMIM ID | | 613552 |
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