Entrez gene ID | | 5430 |
Official gene symbol | | POLR2A |
Full name | | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa |
Aliases | | ,MGC75453,POLR2,POLRA,RPB1,RPBh1,RPO2,RPOL2,RpIILS,hRPB220,hsRPB1, |
Gene summary | | This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq] |
Location | | Chromosome: 17 Locus: 17p13.1 |
Gene position | | 7387850 - 7417933 Map Viewer |
Gene orientation | | plus |
Gene size | | 30084 bp |
Gene sequence |
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OMIM ID | | 180660 |
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