Entrez gene ID | | 5446 |
Official gene symbol | | PON3 |
Full name | | paraoxonase 3 |
Aliases | | ,-, |
Gene summary | | This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq] |
Location | | Chromosome: 7 Locus: 7q21.3 |
Gene position | | 95025687 - 94989184 Map Viewer |
Gene orientation | | minus |
Gene size | | 36504 bp |
Gene sequence |
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