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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for RNF216 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID54476
Official gene symbolRNF216
Full namering finger protein 216
Aliases,TRIAD3,U7I1,UBCE7IP1,ZIN,
Gene summaryThis gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known. [provided by RefSeq]
LocationChromosome: 7   Locus: 7p22.1
Gene position5821292 - 5659678  Map Viewer
Gene orientationminus
Gene size161615 bp
Gene sequence
OMIM ID609948