Entrez gene ID | | 5469 |
Official gene symbol | | MED1 |
Full name | | mediator complex subunit 1 |
Aliases | | ,CRSP1,CRSP200,DRIP205,DRIP230,MGC71488,PBP,PPARBP,PPARGBP,RB18A,TRAP220,TRIP2, |
Gene summary | | The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq] |
Location | | Chromosome: 17 Locus: 17q12-q21.1 |
Gene position | | 37607527 - 37560538 Map Viewer |
Gene orientation | | minus |
Gene size | | 46990 bp |
Gene sequence |
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OMIM ID | | 604311 |
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