Entrez gene ID | | 549 |
Official gene symbol | | AUH |
Full name | | AU RNA binding protein/enoyl-CoA hydratase |
Aliases | | ,-, |
Gene summary | | The methylglutaconyl-CoA hydratase, mitochondrial protein binds to the AU-rich element (ARE), a common element found in the 3' UTR of rapidly decaying mRNA such as c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. AUH is also homologous to enol-CoA hydratase, an enzyme involved in fatty acid degradation, and has been shown to have intrinsic hydratase enzymatic activity. AUH is thus a bifunctional chimera between RNA binding and metabolic enzyme activity. A possible subcellular localization in the mitochondria has been demonstrated for the mouse homolog of this protein which shares 92% identity with the human protein. It has been suggested that AUH may have a novel role as a mitochondrial located AU-binding protein. Human AUH is expressed as a single mRNA species of 1.8 kb, and translated as a 40-kDa precursor protein which is subsequently processed to a 32-kDa mature form. [provided by RefSeq] |
Location | | Chromosome: 9 Locus: 9q22.31 |
Gene position | | 94124206 - 93976097 Map Viewer |
Gene orientation | | minus |
Gene size | | 148110 bp |
Gene sequence |
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