Entrez gene ID | | 5533 |
Official gene symbol | | PPP3CC |
Full name | | protein phosphatase 3, catalytic subunit, gamma isozyme |
Aliases | | ,CALNA3,CNA3,PP2Bgamma, |
Gene summary | | Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca(2+)-dependent modifier of phosphorylation status. In testis, the motility of the sperm is thought to be controlled by cAMP-dependent phosphorylation and a unique form of calcineurin appears to be associated with the flagellum. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. At least 3 genes, calcineurin A-alpha (CALNA1; MIM 114105), calcineurin A-beta (CALNA2; MIM 114106), and calcineurin A-gamma (CALNA3), have been cloned for the catalytic subunit. These genes have been identified in humans, mice, and rats, and are highly conserved between species (90 to 95% amino acid identity).[supplied by OMIM] |
Location | | Chromosome: 8 Locus: 8p21.3 |
Gene position | | 22298596 - 22398638 Map Viewer |
Gene orientation | | plus |
Gene size | | 100043 bp |
Gene sequence |
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OMIM ID | | 114107 |
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