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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PRCP (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5547
Official gene symbolPRCP
Full nameprolylcarboxypeptidase (angiotensinase C)
Aliases,HUMPCP,MGC2202,PCP,
Gene summaryThe protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq]
LocationChromosome: 11   Locus: 11q14
Gene position82611557 - 82535409  Map Viewer
Gene orientationminus
Gene size76149 bp
Gene sequence
OMIM ID176785