Entrez gene ID | | 5584 |
Official gene symbol | | PRKCI |
Full name | | protein kinase C, iota |
Aliases | | ,DXS1179E,MGC26534,PKCI,nPKC-iota, |
Gene summary | | This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq] |
Location | | Chromosome: 3 Locus: 3q26.3 |
Gene position | | 169940220 - 170023770 Map Viewer |
Gene orientation | | plus |
Gene size | | 83551 bp |
Gene sequence |
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OMIM ID | | 600539 |
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