Entrez gene ID | | 55869 |
Official gene symbol | | HDAC8 |
Full name | | histone deacetylase 8 |
Aliases | | ,CDA07,HD8,HDACL1,RPD3, |
Gene summary | | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
Location | | Chromosome: X Locus: Xq13 |
Gene position | | 71792953 - 71549366 Map Viewer |
Gene orientation | | minus |
Gene size | | 243588 bp |
Gene sequence |
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OMIM ID | | 300269 |
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