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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for MAP2K2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5605
Official gene symbolMAP2K2
Full namemitogen-activated protein kinase kinase 2
Aliases,FLJ26075,MAPKK2,MEK2,MKK2,PRKMK2,
Gene summaryThe protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq]
LocationChromosome: 19   Locus: 19p13.3
Gene position4124126 - 4090319  Map Viewer
Gene orientationminus
Gene size33808 bp
Gene sequence
OMIM ID601263