Entrez gene ID | | 5610 |
Official gene symbol | | EIF2AK2 |
Full name | | eukaryotic translation initiation factor 2-alpha kinase 2 |
Aliases | | ,EIF2AK1,MGC126524,PKR,PRKR, |
Gene summary | | EIF2AK2 is a protein serine/threonine kinase that acquires enzymatic activity following autophosphorylation, a process mediated by double-stranded RNA (dsRNA). Activation of EIF2AK2 allows the kinase to phosphorylate its natural substrate, the alpha subunit of eukaryotic protein synthesis initiation factor-2 (EIF2-alpha; MIM 603907), leading to the inhibition of protein synthesis (summary by Kuhen et al., 1996 [PubMed 8812437]).[supplied by OMIM] |
Location | | Chromosome: 2 Locus: 2p22-p21 |
Gene position | | 37384190 - 37333699 Map Viewer |
Gene orientation | | minus |
Gene size | | 50492 bp |
Gene sequence |
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OMIM ID | | 176871 |