Database of mammalian genes
Home

Home Search Browse RAGs User guide FAQs Links Questions Contribute

Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for EIF2AK2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5610
Official gene symbolEIF2AK2
Full nameeukaryotic translation initiation factor 2-alpha kinase 2
Aliases,EIF2AK1,MGC126524,PKR,PRKR,
Gene summaryEIF2AK2 is a protein serine/threonine kinase that acquires enzymatic activity following autophosphorylation, a process mediated by double-stranded RNA (dsRNA). Activation of EIF2AK2 allows the kinase to phosphorylate its natural substrate, the alpha subunit of eukaryotic protein synthesis initiation factor-2 (EIF2-alpha; MIM 603907), leading to the inhibition of protein synthesis (summary by Kuhen et al., 1996 [PubMed 8812437]).[supplied by OMIM]
LocationChromosome: 2   Locus: 2p22-p21
Gene position37384190 - 37333699  Map Viewer
Gene orientationminus
Gene size50492 bp
Gene sequence
OMIM ID176871