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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for LGMN (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5641
Official gene symbolLGMN
Full namelegumain
Aliases,AEP,LGMN1,PRSC1,
Gene summaryThis gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq]
LocationChromosome: 14   Locus: 14q32.1
Gene position93215047 - 93170152  Map Viewer
Gene orientationminus
Gene size44896 bp
Gene sequence
OMIM ID602620