Entrez gene ID | | 56647 |
Official gene symbol | | BCCIP |
Full name | | BRCA2 and CDKN1A interacting protein |
Aliases | | ,TOK-1,TOK1, |
Gene summary | | This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq] |
Location | | Chromosome: 10 Locus: 10q26.1 |
Gene position | | 127512104 - 127542264 Map Viewer |
Gene orientation | | plus |
Gene size | | 30161 bp |
Gene sequence |
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OMIM ID | | 611883 |
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