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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for BCCIP (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID56647
Official gene symbolBCCIP
Full nameBRCA2 and CDKN1A interacting protein
Aliases,TOK-1,TOK1,
Gene summaryThis gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]
LocationChromosome: 10   Locus: 10q26.1
Gene position127512104 - 127542264  Map Viewer
Gene orientationplus
Gene size30161 bp
Gene sequence
OMIM ID611883