Entrez gene ID | | 5684 |
Official gene symbol | | PSMA3 |
Full name | | proteasome (prosome, macropain) subunit, alpha type, 3 |
Aliases | | ,HC8,MGC12306,MGC32631,PSC3, |
Gene summary | | The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified. [provided by RefSeq] |
Location | | Chromosome: 14 Locus: 14q23 |
Gene position | | 58711593 - 58738726 Map Viewer |
Gene orientation | | plus |
Gene size | | 27134 bp |
Gene sequence |
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OMIM ID | | 176843 |
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