Entrez gene ID | | 5699 |
Official gene symbol | | PSMB10 |
Full name | | proteasome (prosome, macropain) subunit, beta type, 10 |
Aliases | | ,LMP10,MECL1,MGC1665,beta2i, |
Gene summary | | The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome. [provided by RefSeq] |
Location | | Chromosome: 16 Locus: 16q22.1 |
Gene position | | 67970753 - 67968407 Map Viewer |
Gene orientation | | minus |
Gene size | | 2347 bp |
Gene sequence |
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OMIM ID | | 176847 |
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