| Entrez gene ID | | 5705 |
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| Official gene symbol | | PSMC5 |
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| Full name | | proteasome (prosome, macropain) 26S subunit, ATPase, 5 |
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| Aliases | | ,S8,SUG-1,SUG1,TBP10,TRIP1,p45,p45/SUG, |
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| Gene summary | | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
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| Location | | Chromosome: 17 Locus: 17q23-q25 |
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| Gene position | | 61904810 - 61909387 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 4578 bp |
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| Gene sequence |
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| OMIM ID | | 601681 |
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