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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PTBP1 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 5725 Official gene symbol PTBP1 Full name polypyrimidine tract binding protein 1 Aliases ,HNRNP-I,HNRNPI,HNRPI,MGC10830,MGC8461,PTB,PTB-1,PTB-T,PTB2,PTB3,PTB4,pPTB, Gene summary This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq] Location Chromosome: 19   Locus: 19p13.3 Gene position 797392 - 812327  Map Viewer Gene orientation plus Gene size 14936 bp Gene sequence >PTBP1:737392..752327:Length=14936 TGCGGGCGTCTCCGCCATTTTGTGAGTCTATAACTCGGAGCCGTTGGGTCGGTTCCTGCT ATTCCGGCGCCTCCACTCCGTCCCCCGCGGGTCTGCTCTGTGTGCCATGGACGGGTGAGT CGCACGTCGCCCCGCGCCCCACCGCCCTCCCCGCGCCGCAGCCCTGCCCCCGCCGCCGCG CCGGCCTCCCCGGGGCCGATCTCGCCCCCTCTCGGGCGGGAGGGGGCGGCGGGCTCTCCC CTTCCTCTCCGCGTGGCGGGCGCGGGTGCGGGGCGGGTCAGGGGCTTCCCGGGGGTCTGG CCGCGTCCCCATCCCCCGTCCGGCCCGCTTCCGGCCCCCGCGCGCCCCGTCCCTAGCGCA CGCGGCCTCCCGCGCCCCTCCCCCTCCGCGCGCGTCCCCGCACTTCGCCTTTGCCCCGCC TCGGCGGCGCGCGGCCCTTCCCGCTTCCCGTCCGGCCCTCGCGCGCCCGGATGGCCCTTC CCGCCTCCCGTCCGCTCCCCTCGTGCGCCTGCGTAGCCCGTCGCGCGTCCCCGTTGGCCC CAGCGCGCGTGCGCGGCCGCCATCGGGGGCGCGCGCCTTTCCCGCCGCCCGGACTCTGCC CCCGGCGCAGCCCCGGAAGCGCAGGCGGGGCTGGGGCGGCCGCCGGGAGGGAAAGCTGGC GCCGGGGCCTCGCCGCGGGCCCGAGTCTCTGCGCTCCCCGCCCTACCCCTGCCCCCCGTG CGCCCCGGGCCGCGGCCAAGGGGTTTCGGTGATCTCGGGAGAGAAGCGGCCGCCCCGAGG GTCTGTCCTCCGCCCCGGGGCCGGAGGGGCCTCTCCAGGGACCCCCGCGGGCGCCGTCAT GGGGAGGGGCCTTCCCGGCTCTCGGGCCGGGGCAGCCTTTCCGGGCGGCTTTGCTGGGCG GGCTTCCCTTGGGAGAGGTGGGAGCCCCCTCCAGAAAGGCCGTGTCCCGCCGAGCGCTTC CTGCGCGAGGCCCTCCCTGGGAATAGGAAGCGGGAGAGGCTGGAGATGTTTCGCATTCTT TCCGTTTTCCTGAGAAGTTTTTCTTGGGTTCAGTCACTTTTAAAAGTCTGTTAAACGTGG TCCGTGCAGTCTGTGGTGTCAGAAGAGGCGCAGCCCTAGAGTGGGTCTGGACCCCTTAGC ATGCGTGCGGGCAGGTGGGTCCTGCAGACGGCGAGACGAGGGCTCCCCGCTCTCGGACCC AGCACCGCGGGCTCGGGGGCCGCGCACTCGCCTCCCGGAGTGAGGCAGGAGGCCCGGAGG CTGCCCTTCCGACGGACGCTCCGAGTCACTTAGGGCCTCGCCGGGAGTTGCAGTGGCCGG GAGAAGCCGTGGGGAGCTCACTGTTGGGTCAGGACCTGGCCGGGGCTGAAGGGAGGGCCT CGGACAGTCCGGCTTTCTATCCACCTTCCCCCCGGGGTGTCCCGAGGAGGGAGAGTCGGG TCGGGCGGGGCTCGGGTTGATCAGTAACTGAGGCTGTGTTCTGGTCGGTCTGTTAATTTT TATTGACGGTTTCCACGGCCGCCTCCTGCTCTCCTCGGTGGATCGGGCTCCACTCTGCTG AGAGGCACCCTCTTGGGGGCCCACCCCTACCCGGGTGGAAGCTCTGGCCCAGGCCTGTGA GTTTGCCAGTTTCAGCCTCTCCGAGGCGTTTCCAACTTACTGGAAAGCACACAGCAGCCC TTGAACCCTCTCAGCGGCATCTAGCATTCCTCGGGGCTTCCGATGGGGGTGTCTTTGTCT TGGAACGTGTGGGGCCTGGTCCAGAGGTGGGGCCTGGGGTCCTGCTGGGAGGGAGGGGCG CCAAAGGACAATGGTGGCCCCTTTTCAAGTTGCAGTCAAGTGGACGGCTCACTTCCCTGC CCTTCTGAGCTTTCTCTAGCGGGGCCTCGTGCAGCCAGAGGGAGCCCTGCGGAGGTGGCA GCTGCAGGGACCTACGGGCTCTCCTGGCCCGGGGACAGCTGGGTGCTCCTGCTGCTGAGT GGCCACCAGGCTAACGTTGTCTCCTTTCTTTCTCTCTACAGCATTGTCCCAGATATAGCC GTTGGTACAAAGGTAGGCACTTCTCACTTTGCTTCTCCGTGACGCTCCTCTGACCTTGTG CCGACCCCGGGGGCCACCCCCCAGCGCTGTTGCGTTGGCTAGAGGGCGCTTTTCCATTCC TAAGGGGCACTACCCTTGGTCTGGAATCTGGAGTTGGGCGGTAGGGTTTGAACCCCGGGC TCCAGTGCCCGTGAGTTTTGGGGGCTTGGGTTTGCTGGCCGCCCCTCAGGTCTGGAATCT GAGCTGCTCTTCGGTTCTTGCTGTCAGCAGCGAGGGCTCTGTGTGCCCCAGGCCTGCCTT TGGAACTTCTGCCTCTAGAGGCTGGAATCGTGCCGTTCAGTGGGAAACCTCATGTTGTGG CTGCCTGGGAGACTCTTGGTTTTGATAGGAAAAGAGCCACCTGGCTGTGGAGGGGACCTG GATAGAATCCAGCCTATTTGAGTGGCTAGGATGGGCATTTACTGGTTGATTTTGACGTTA AGTTTTTTTGTTTTTGTTTTTGTTTTTTATTTTTGAGATGGAGTCTTGCTTTGTCACCAG GCTGGAGTGCAGTGGTGTGATCTTGGCTCACTGCAACCTCCACCTCTCAGGTTCAAGCGA TTCTCCTGCCTCAACCTCCTGAGTAGCCGGGATTACAGGTGCCCACCACCATGCCCAGCT AATTTTTGTATTTTTTTTTTTTTTTTTTGGTAAAGATGGGGTTTCGAACATTGTTGGCCA GGCTGGTCTGGAACACAGGTGATGCACCCCCCTTGGCCTCCCACAGTGCTGGGATTACAG TTGTGAGCCGCCAGACCCGGCTGACATTAAGTATCTTTGATGGCATCTGGTTAGAACAGC AGCAAACTGTCAAAGGTGGTGTTTGGGGCAAGAGAAAAATGAATGTGCCACGTCTCTGGG GTGTGCGAATCTTGCAGCCCCATGGAGGGTGAGGCCAGGGCTCAGCATGTGAGGAAAGGG GGTCAGAACCTGGAGAAGAAGAAGGTCCTGGGGAGGCGATTCTCGAGGGAGCTGTAGTCC TCGCTTAGCTGGGGTAGTTGGTTAATGATTCTGCTGGTCATTGTGGGTTGAGGGGGCTCC CGACTTCAGGGCTTGTGCCCCGAGAGCCTCCCGCAGGGCGAGCCCACAGTGGTGGCGTCC TGAGCCAGCAGCCAGTTGGTTTCTGGTCAGTCAGCAGTGGTGCCTGGGCCAGGTTTCGGT TTTTCCCAAGTGGACTGCTGTCTTTACGCGCTGCCTGCCCCGATCTTCCTGGAGATAAAA CCTGTTTGTTCAGTGTGGGAGGAGGGAGAGGTACTTTCATCTGAAGCATTTGCAACAATC CCTAGATGTGTCTGGCTTGCAGGCAGTCGTCTCTTCCCTGCTTCTGTGGGCCTGCTTTCC AGCTGGAGTGGCCCTCAGCTTCCATCGGGTGGTCCTTGAGCCCTCCTCTGCAGTTCCTAG GGGGCTCCTGGGCTGGGACGTTGAAGCCCAGCCAGGACTTGAAGCCTGCGGGAGGGATTT TGCCACAGGGCAGGGTTAGGGCTCCTGCTGGGTGCAGGCCCTGGTAGGAGGACGGGGTAG TACCCTGACCCAGATGATACCCCCCCTCCCCCCCACCACCAGGGAGCCCTCAGCTGACCT GGGCCCACACCTGGCTACGCTGTCCTTTAGCCCAGGACAGAGCAAGCTCTTGTTCAGTGT GGGGTTAAAGACACCTAGGAACTGTGCTGTAGGGCCCCAGCTGCAGACTGGAAGTCCTGG GGCGTTTCCTGTCAATCTGTGTGCTTCAGGACAGGTGCCCTGAAGGGACCCTCCTGGGGT ACCTGGCAGCTGCTGTGAAGGCAGTGGAGGCGCTAGGCCCAGCTCGTGTCTCCTGGTTGC TGCCCTGTGGAGCCTCGGAGCCTCCAGGTGTCCCTTCCGTTCTGCTGGGGCGCCGTTGAG CTGAGCCAAGCCGGCCTGTGCCGCCTGGGCAGGCATGGAGTTTGCTGCCGCAGACAGTTG TGGGCAATGCCAGGCCACTTGCCCATGGGAATGAGATTAGGGCTTCAGGCAGGCGGCCAA GAGGACCGCTCAGAGGAAGCGGCCCCGCCCACCACTCCAGTCAAAGACAGGGTCCAAGAT GCCCTTTTTAAGGTTTGTGCAGCCAGCACATGGGAGCCGCATGGGCGCTTGGCCACTCTC CAGCTTGGGGGAGGACCAGCCCTGGTGTCCTGGACGGGGTCGGCTCCTGGGCTCCCCCAG CCTCTGAGCTGGAGGGGAGAGCAGACAGGAAGCGACTTCCTGTGGGAGGCGAAGGTTGGA GGCCCTGCGTCTCAGGTGCACCCATCCTCCCTTCCTCCCGTCCTCCCTTCCTCCGGTCCT GGCACTGCTGTGTTTTCTGATCGCGTGGTTTCCACCTGAGGCGGCTGGCTCTGACCCCTT TCCCCTGGGCCTGCGCAGCCCCGCCTTGTGCTCATAGGGGGCCCCAGACTCTGAAAGCGA GAGGACTCGAGGGTCTGTTTTCAGTATTTGGCTTCATCTGTGTCCGGCCGGAACCTCAGG GCCGCCGTGACACTGGACACTGTTCATTCTCTGACCCTAAAGTCTTGGGGACTGAACAGG TGCCATTTGGGTGGGCGCCGGGCCTGTGGACCCTGAGTGATTCCTGGTTCCGGCCCTTGT GGCTGCTCGATTGCTTGTTTGGTGACGCCCTGAGTGCTTGTGGGATTGGTGGGAGACTCA GGGCTGCAGTTAGAGGTCTCATTGGCAAGGGCCAGTCCCTGTTCCCCATCCTCCTTGAGC AGGTGCCGGAGTCTCCCGAGGCTCTTGCCGTCCGCGTCGGGAGGAGGCAGCTGTGGGGCT TTGGAGGCTCGGGCAGTCTTCCTTCCAGGAAGCTCTTGAGCCAGGGCCAGGGCAGGAGTG GAGCTGAACGTGGGTGGAGGGGAGGCGGCCTTAAGAGAAGACCAAGCGCAGGCTCGGGGA GGCCAGCGTTGGTGGGGGCTCTTTGGCCAGGTGTGGGGGCAGCTCCTTGACCAGGCATGG GGGTGTGTGGAGCTGGGGGTTGTCTGAGGGGGGACAGGGTGTGATATCCACTGGTTCTTT CTGATGCGATGGCCCTGGGCCCTTCAGCAGGTGGGGGCAGGCTCTTGGCCTCAATCCTGA TACGGGAGATGGAGGCTCCTTTGTTCCCTGGGATGGCCCTGTCCTGGGGGGCCTGGGCGT TGCTGCCCTCAGCGCCTGCAGAGGCTCGCTTTGCAGACCAAGCGCCTGTGCTCCAAGGTC CTCAGACCCGAGCTTTGTTTTCTGTGTAACTAAGGGCCGTAACCAACGTCTCCTCCAATT TCACTCTTTGAATAAACGTGTGTCTTCAATCCTTGCAGCGGGGGGGATGTCTGCCGTCCT GAGCCTAGGATCAGTCTAGTGCAATTCTTAGAAGTTGATCCAATTACATAGAAATAACCA GTGAATAGATTGTTTCTGGAGAGAAAATGGACAGGTCAGAAGTGATGGAGCCGCTGTGGA GCTCCCCCGGCCCTAGTCACGGCCGCGATACCAGCGGATCACTGGGCGGGAGGCCGTGTC TCTAGTCCTCAGTCTCGCGTGTGCAGAGACGGAGGTCGGGTTTCTTTTCCGGGCTGGAAA ACAGGAGAGGAGGGGCTCCTGCGAGAGTGAGGGAGGCAGCGCTATAATTTGGTTCTCTTG CGAGGCCACCAGAAGTGAGGACGGCTGCCTGGGCCCTGCCGTGTGCTGCTGGGGGGGCTG GCTCCATGGAGGGGGTCCTCTGCCCTGCTGGCTGGTGGCTGAGGCCCCAGGCCTGTGCCC AGGGCCGCTGGCAGCACAGTGAGGCCACGTCCACAGCAGAGTTGGCCGTGGAGATAGTGT ACGTGGTGCCCTCCGTAGCTGAGAGCCTCCCAGCCCCACACTGGCTGAGTACCCAGGGCT TCCAGAATTTGGAAAAAGGAGCAGTGTTTTGGTCGTGGAGCTGTGGGGTGCCGTGCGCGT CCATGGGCTGGGTCTGCGCTCAGGCTGCCCTGCCGTGGAAGTGTGGGTGTGGGTATGGGT TGGGGGTCTGGGACCCCAGGCAGCCCAAGTGGGAGCAGGGCCGGCCGGTGGGGAAGGGAG GCTCTGGCCTGGTGGGAAGTGCAGCTCCGCGTTGTCCCTTCTCTTGCAGCGGGGATCTGA CGAGCTTTTCTCTACTTGTGTCACTAACGGACCGTTTATCATGAGCAGCAACTCGGCTTC TGCAGGTAAGGCCGGGACTCGGCCCAGGGCAAGACCCGTGGGTGTCTTTCCCTGGAACAA CGTTACGTTCTTGTTCTGGGACTCTACTTTCCATCTCCAACTGCAGGGGCCCATGGTCCA CGCTACAGACCCAGGTCCAAGTTCTCGCTGCAGAGAATTTCCAGGGAGGCGCTGGATGGA TGGTCCAGGCTGGCACTTGGACCTGTGGGCGGGTTGTCAGGAGCTGTCGGGAGCAGGGGT CCTGACTGTGCAGGTCTTGGCCTCTCGCGCTGCTGGTTCACATGCACCCTCCTGGGGCTC AGGGTTGGTCTCCGTAGCAGGCAGGGCTCTAGGGGGATAGCAGGGACCTTCCTCTGTGGG CTCCTGCGAGTTGGTGCCTGCATCTCATGGCACCCCCTTTTCAGCAAACGGAAATGACAG CAAGAAGTTCAAAGGTGACAGCCGAAGTGCAGGCGTCCCCTCTAGAGTGATCCACATCCG GAAGCTCCCCATCGACGTCACGGAGGGGGAAGTCATCTCCCTGGGGCTGCCCTTTGGGAA GGTCACCAACCTCCTGATGCTGAAGGGGAAAAACCAGGTACCTGAGCCGCGTTTCTCCGG GGTGCTCACACCGTGCAGGCGGGGACGAGGAGGGCCCAGCGCTCACTGCCTCCCCAACAG GCCTTCATCGAGATGAACACGGAGGAGGCTGCCAACACCATGGTGAACTACTACACCTCG GTGACCCCTGTGCTGCGCGGCCAGCCCATCTACATCCAGTTCTCCAACCACAAGGAGCTG AAGACCGACAGCTCTCCCAACCAGGCGGTGCGTGGCCCCGCGGCGGACCCCAGCAGCCCG GGGACCTCGGGGGTGGGCCCAGCCGCAGGGGCCGGGGACTCACGGCTGTGCCTCCCACAG CGGGCCCAGGCGGCCCTGCAGGCGGTGAACTCGGTCCAGTCGGGGAACCTGGCCTTGGCT GCCTCGGCGGCGGCCGTGGACGCAGGGATGGCGATGGCCGGGCAGAGCCCCGTGCTCAGG ATCATCGTGGAGAACCTCTTCTACCCTGTGACCCTGGATGTGCTGCACCAGGTGAGGTGG TCCCATCACCGCCAGGGCAGGTCGGCTGCTATTGCTGTGGGCACAGGCACACGGGAGGGG CCTGGCAGGGCTGGTGGGCACCGGGCAGGAGCTCATGCTGTGGCCCGGGACCTGCAGATT TTCTCCAAGTTCGGCACAGTGTTGAAGATCATCACCTTCACCAAGAACAACCAGTTCCAG GCCCTGCTGCAGTATGCGGACCCCGTGAGCGCCCAGCACGCCAAGCTGGTGAGTGGGGCT CCCGGGACGGCGCCCGCCCTGGCCCTGGCCCGGCGACGTCTCACGGTCCCTCTCCCCTCA GTCGCTGGACGGGCAGAACATCTACAACGCCTGCTGCACGCTGCGCATCGACTTTTCCAA GCTCACCAGCCTCAACGTCAAGTACAACAATGACAAGAGCCGTGACTACACACGCCCAGA CCTGCCTTCCGGGGACAGCCAGCCCTCGCTGGACCAGACCATGGCCGCGGCCTTCGGTAA GAGGCTGCCCGACGCGGCGCCAGTGTGCAGAGTGGTCTATTAGGGCCGCTCAGTCCGGAG CCCCGGCGGCACGGGCCCGGCCCTGCACCAGGGTGATGCACCTGCTGCTCTCTGCACGGC CAGCACAGCACGGTCCAGTGTCCCCCACGTCGGGACCACGGCCCCCCCTGGAGCAGCGGA TCTGCCCGCGAAGGCTCTGCCGGGGCCGCCCGCCGGCCGGGTTGGGGCCCATCCCGCAGC ACAGCGCCCGCTCGCGGTGGAGGTTGTGGGTGCGATGATTAGTGTCTCATTTATTTCTAG GTGCACCTGGTATAATCTCAGCCTCTCCGTATGCAGGAGCTGGTTTCCCTCCCACCTTTG CCATTCCTCAAGCTGCAGGTATTCAAACGCTTGGTCTTGGTTCCCCAGCGACTGCATGCC CACACCACCTTCCCAGGCAGCTCCGCATCCACGGCGGCAGCCTGGGCGGACTGGGCACTC GAGTGCCAGGTCAGGGGCCCTTCCCGGGAGAGGGGACGCCACGTCCACAGAGCAGGCTTG GCCAGGGCAGTGGTAGGACAGGGCTGTGGAGGCCCACGTGTGGACGGCGCCAGCCAGAAG CCGCTAATCGCACAGTCTTTGTGGTCTGGTTCCCTTCAAGCACCTCCGGGCGAGCGCGAG GACCGCCAGTGGTTGGAGGGATGTCTCTAGTAGTTGAATTTGAGTGGCCTGGTAAGCGCG CGGCCCGAGGCTGAGCAGCATGACCGGCGGCGGGACGTGTGTGCGTGGCCGTCCTCCCGC TTCCCTTCTGGGACCGGGGCCCGGCCGCCCCAGTGCTGGCCGTGGACGGAGCAGCGCGTG CCGCCCGGCGGCCGCCTCGTCTGCATGGAGGCATGGGCGCGCATGCGCGGTGGTCCCGGG ACGGGCCCTGCTTGCCGAGGGCCCCGTGTCTGTGCTGGCGGAGCCGGAGCTTTTCTGTGC TGTGGGCGGGGCGCATGCAGATGAGCCCAGGCCCGGCCCGGCCCGTGCTGTGAGGAGAGG CGGGCGCTGGTGCAGGAGCCGGCGGGTGGCTGTGCGGGGGTCGGACGACCCCACAGGCAC CCAGGGTAGGGCCAGAGCCAGGGCCGCCTCCCGCGCGGCTCGGCTCCTCGGTGCATGAGG ACGGGGAGCGTCGGCCTCTCCCACTCTGCGGTGGAGTCGGGGGCGCCGCCGCTCATCTCA CCTCCTGCTTTTCCAGGCCTTTCCGTTCCGAACGTCCACGGCGCCCTGGCCCCCCTGGCC ATCCCCTCGGCGGCGGCGGCAGCTGCGGCGGCAGGTCGGATCGCCATCCCGGGCCTGGCG GGGGCAGGAAATTCTGTATTGCTGGTCAGCAACCTCAACCCAGAGGTACGTGGGCTTTTC CTCCGCGCCGCCGTTCCTCCCGGAAGAGCGAGCAGGGGATGTTGTGCTCGGGCTCGGGTC CCGGAGCAGCGCCGCCCCTCGCTGTGTCTGCGCCTCTGCCCTGGCAGCCCCTCTGCTGCA GCGCTGAGACCCTCCTTTTCCAAGATGGCTTGAGTTTTCCTCTTTTCCTGAATTCACATC TTGGTTCGCGTTTTCTCTTGCATGATACGCAGAATGAATTATTTTTTGGTTACCCAAAGG CAATCTAAAAATTACTTGGAGCTGAGCAGGGCGCGCAGTTCAGAGCCCCAGCAGGCCGCC CTGCTGGTCAGCGGGACACACAGGGTTAGCGCGGCGGGGTGTGGGCAGCCCCTGTGGCTC GAGAGCCTGTCACTTAACTGGTGGATCCGTTATTTCCCAGAATGGTTAAATTCCCCTCGG GGAGAGCTTGGGTGAAACAAGAGGCCCAAAATATGTAACTCTTGATGGATGGGATCCTCC TGGAATCAGCATTTCAGGCTGTTCTGTTTCCCGGCAACTCCTGTGACTTCCTCAAGGCGG TGCCCAGCCTGGCCCTCCCTCGCGGGGGCCCAGGACGCACTCCCTGCCTGTGCCTCTTAC CACGAGCCGGGTGCTGTCCCTCCAGCTCCTCCTGAGCGAGGCCGTGCACTAACAGACTCG ATCTCCCTTCACGCCTGTAATCGTCCTTAGAGACTGACTTGTGCCACAGCTGCGGGAGAC AGCGCTGCTGCAGGGCTTGGCTGAGGTGGCCGCGAGCGGAGCTGCACGCGCGCTCCTGGG GGGCGTGGTTGGGATCGGCTTCTGGGAGCCCCTCCAGCAGCGCTGTCTCTGCCGGCATGT GAGTGAAGGTGCTTCTCTTACCGTGTGCCCGTCGAGGTAAACCTGTAACTGGAATGTGTG TGGAGTGTGACTGATAGAACACTACCTGATTCTTATGTATTTACTGACCTGTGTTTTTTT GCTACTTTTTTTCTTTTCTCCCCTTCCCCTTTCCCTATTTTTTTTCTTGCCCTGATCCGG AATTTCTTTGCCAACTGACTGCACGGTACTTCTGCTTCCTGTTGTTGCTTGAAACAAAAC AAAAACATAAACAAATAAAAAACAAAAATTCCCCCTCAAACCCTGCTCTCCGGAAACCAA CCTGCCCTTGAATATTAACATCCTGACAACTTCATCATCCATCAACCACTGCACGCCTGC GGGGACTGTCTTCCTCGTGTGGACGATTGGCAACTCGCCCCCCTTGACCTCTCCCTCTCC CCTGTCCCTCCGCTGCCTTGCTCTGCTGTCTCTAAAGAGAGTCACACCCCAAAGCCTCTT TATTCTTTTCGGTATGTTATCGTTCACACTTTTATTACCTTGTTTTCATTAATTGAGATG ATTTTGATGCCCTGAGACGTATTATGAGTTTGCGGTTTGGCACTCTGATGCTCCGTGGCA TCCGCCTCGTTTTATGGTTTGCTTTCGGTTTGCGAATTTTATTTGGTCCCGTAGATACGT ACGCATGGTTTATCGCCCTGCATGCTTTTCAGAGTTAGACCTGTCGGTGGCATATGCCAC CGTGGCCACCCGCTGGCAGCTTACCTGTCCTGGATGCTATGACTTTGCTGAACGGAGCTG CTCCTGTTAGCGCGCCCTGTGGCTGCGAGACGCAGCTCCGCAGTGGCCGATAAAGCAAAC CCGGCCGGGCTGAGCCGGGCCTTGTGGGGGTGCGCGGGGCCGGGGCTGACGGGGAGATGG GCGGGGCAGGCAGCAGGAGACTCAGGCCCCATCCCTGGGCTTTTGAAGGCGTCTACGGTG ACGTGCAGCGCGTGAAGATCCTGTTCAATAAGAAGGAGAACGCCCTAGTGCAGATGGCGG ACGGCAACCAGGCCCAGCTGGGTAAGAGGCCGGGGCGGCCCCGGGGTGGAGGGGGCAGGG GCGGGGGCTGCGTTCCCTCTCGGGCGCCTGGTCACGCGGGTGCTGCTCCCCCAGCCATGA GCCACCTGAACGGGCACAAGCTGCACGGGAAGCCCATCCGCATCACGCTCTCGAAGCACC AGAACGTGCAGCTGCCCCGCGAGGGCCAGGAGGACCAGGGCCTGACCAAGGACTACGGCA ACTCACCCCTGCACCGCTTCAAGAAGCCGGGCTCCAAGAACTTCCAGAACATATTCCCGC CCTCGGCCACGCTGCACCTCTCCAACATCCCGTGAGTGCTGGGCCGGGGGGCTCATGGGG CCGGGGGCGGGCAAGGGCTCTGCTTGGCTGTCCTACCGCGTCGGTGTGTGGACTTCTGGC GTTTCCAGAGTGCAGGTCGGGCACCTCTTACCCCAAACCTGAAGTACTGCAAGGCCTGGA GCTTGAGCCGAGGGCTGCTCAAGGGAGGGGGTCGTTGGACACTTTGGAGGTTTTGGCTCA GGGGATGCTCCCTGTGAGAATGTATAATGCACACATTTATTTATTTATATTTTTTGAGGC GAAGTCTTGCTTTGTCACCCAGGCTGGAGTACAGTGGAACGATCTCGGTTCACTGCAACC TCCGCCTCTTGGGTTCAAGTGATTGTGCCACCTCAGCTTCCCGAGTAGCTGGGACTGTAG GCACCCACAACCACACCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATA TTGGCCAGGCTGATCTTGATCTCCTGACCTTGTGATCCGCCTGCTTCGGCCTCCCAAAGT GCTGGGATACAGGCGTGAGCCACCGCGCCTAGCCACATTTATTTATTTATTTATTTATTT TACTTATTTTGAGATGGAGTCACGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGGGATCT CTGCAAGTTCTGCCTCCTGGGTTCATGCCACTCTGCTGCCTCAGCCTCCCGAGTAGCTGG GAGGGACTATAGGTGCCCGCCAGCACGCCCGGCTAATTTTTTGTATTTTTAGTGGAAACG GGGTTTCACTGTGTTAGCCAGGATGGTGTCGATCTCCTGACTTTGTGATCAACCCGCCTC GGCCTCCCAAAGTGCTGGGATAACAGGTGGGAGCCACCACGCCTGGCCTAATGCACACCT TTATAATCCCAGTACTGTGGGGGGCCGGGCAGGGGATTGCTTGAACCCAAGAGTTAAGAC CAGCCTGAGCAATAAAGTGAGACCTCTGTCTCTACAGGAACAATTGGTTAAAATTAGCTA GGAGTGGTGGTGTGCACGTCAGGTCCCAGCTCTTCCGGATTGGGAGGTTGAGGTGGGAGG TTCACTTCGCGCTCAGGAGGTTGAGGTTGCAGTGAGCTGTGATTGCACTGCCAGACTCCA GGCTGGGCGGCAGAGTAAGACCCTGTCTGTAAAAATTACATAATGCAAGTATTTGGAAAT GCAGGTACATCTGGCCCCAAGCATGTCAACCAGTAGTAAGCCCTTTGATATTTAACACGT TACTTGTGAAATGTTATCAGAAAATCAACAAGGGGCCTGGCAGAGTGGCTCACGCCTATC ATCCCAGCACTTTAGGAGGCCGAGGCAGGCAGATCACCTGAGGTCAGGAGTTCAAGACCA ACCTGGCCAACCTGGTGAAACCCCGTCTCTACTAAAAATAAAAAAATTAGCCTGGCATGG TGTTGCGTGCCTGTAATCCCAGCTACTTGGGAGACTGAGGCAGGAGAATCACTTGAACCT GCAGGCGGAGGTTGTGGTGAGCTGAGATCACGCCACTGTGCTCCCGCCTGGGCGACAGAG CAAGATTCCATCTGGAAAAAAAAAAGTGGAGGAGCGTGGTACTCTGTTTCTGCAAACTTG TAGATGCCTGGTTTCGTTAGAAGCTGCTTCAGACCATTGTGGACATGATTTGATACCCCA TTTCTGGGCTCCTAAAAGGCCCTACGCCTTCCCCGGCTACTCTGAAAACTAGTCTGGGGA AAGCCTCGCGGACCTGACTGGGCGCCCCCACCCCCACGCGGCCCCAGGCTCACGCCTTTC TCCTCCCACAGGCCCTCAGTCTCCGAGGAGGATCTCAAGGTCCTGTTTTCCAGCAATGGG GGCGTCGTCAAAGGATTCAAGTTCTTCCAGTGAGTATGAGGCGGGCTGTCCCTGGCTCTC CCCAGGCTGCCCTGCGGCCGGCCCTGACCCCCTGTCTTGCAGGAAGGACCGCAAGATGGC ACTGATCCAGATGGGCTCCGTGGAGGAGGCGGTCCAGGCCCTCATTGACCTGCACAACCA CGACCTCGGGGAGAACCACCACCTGCGGGTCTCCTTCTCCAAGTCCACCATCTAGGGGCA CAGGCCCCCACGGCCGGGCCCCCTGGCGACAACTTCCATCATTCCAGAGAAAAGCCACTT TAAAAACAGCTGAAGTGACCTTAGCAGACCAGAGATTTTATTTTTTTAAAGAGAAATCAG TTTACCTGTTTTTAAAAAAATTAAATCTAGTTCACCTTGCTCACCCTGCGGTGACAGGGA CAGCTCAGGCTCTTGGTGACTGTGGCAGCGGGAGTTCCCGGCCCTCCACACCCGGGGCCA GACCCTCGGGGCCATGCCTTGGTGGGGCCTGTGTCGGGCGTGGGGCCTGCAGGTGGGCGC CCCGACCACGACTTGGCTTCCTTGTGCCTTAAAAAACCTGCCTTCCTGCAGCCACACACC CACCCGGGGTGTCCTGGGGACCCAAGGGGTGGGGGGGTCACACCAGAGAGAGGCAGGGGG CCTGGCCGGCTCCTGCAGGATCATGCAGCTGGGGCGCGGCGGCCGCGGCTGCGACACCCC AACCCCAGCCCTCTAATCAAGTCACGTGATTCTCCCTTCACCCCGCCCCCAGGGCCTTCC CTTCTGCCCCCAGGCGGGCTCCCCGCTGCTCCAGCTGCGGAGCTGGTCGACATAATCTCT GTATTATATACTTTGCAGTTGCAGACGTCTGTGCCTAGCAATATTTCCAGTTGACCAAAT ATTCTAATCTTTTTTCATTTATATGCAAAAGAAATAGTTTTAAGTAACTTTTTATAGCAA GATGATACAATGGTATGAGTGTAATCTAAACTTCCTTGTGGTATTACCTTGTATGCTGTT ACTTTTATTTTATTCCTTGTAATTAAGTCACAGGCAGGACCCAGTTTCCAGAGAGCAGGC GGGGCCGCCCAGTGGGTCAGGCACAGGGAGCCCCGGTCCTATCTTAGAGCCCCTGAGCTT CAGGGAAGGGGCGGGCGTGTCGCCGCCTCTGGCATCGCCTCCGGTTGCCTTACACCACGC CTTCACCTGCAGTCGCCTAGAAAACTTGCTCTCAAACTTCAGGGTTTTTTCTTCCTTCAA ATTTTGGACCAAAGTCTCATTTCTGTGTTTTGCCTGCCTCTGATGCTGGGACCCGGAAGG CGGGCGCTCCTCCTGTCTTCTCTGTGCTCTTTCTACCGCCCCCGCGTCCTGTCCCGGGGG CTCTCCTAGGATCCCCTTTCCGTAAAAGCGTGTAACAAGGGTGTAAATATTTATAATTTT TTATACCTGTTGTGAGACCCGAGGGGCGGCGGCGCGGTTTTTTATGGTGACACAAATGTA TATTTTGCTAACAGCAATTCCAGGCTCAGTATTGTGACCGCGGAGCCACAGGGGACCCCA CGCACATTCCGTTGCCTTACCCGATGGCTTGTGACGCGGAGAGAACCGATTAAAACCGTT TGAGAAACTCCTCCCTTGTCTAGCCCTGTGTTCGCTGTGGACGCTGTAGAGGCAGGTTGG CCAGTCTGTACCTGGACTTCGAATAAATCTTCTGTATCCTCGCTCCGTTCCGCCTT OMIM ID 600693