Entrez gene ID | | 57282 |
Official gene symbol | | SLC4A10 |
Full name | | solute carrier family 4, sodium bicarbonate transporter, member 10 |
Aliases | | ,NBCn2,NCBE, |
Gene summary | | This gene belongs to a small family of sodium-coupled bicarbonate transporters (NCBTs) that regulate the intracellular pH of neurons, the secretion of bicarbonate ions across the choroid plexus, and the pH of the brain extracellular fluid. The protein encoded by this gene was initially identified as a sodium-driven chloride bicarbonate exchanger (NCBE) though there is now evidence that its sodium/bicarbonate cotransport activity is independent of any chloride ion countertransport under physiological conditions. This gene is now classified as a member A10 of the SLC4 family of transmembrane solute carriers. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
Location | | Chromosome: 2 Locus: 2q23-q24 |
Gene position | | 162480845 - 162841786 Map Viewer |
Gene orientation | | plus |
Gene size | | 360942 bp |
Gene sequence |
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OMIM ID | | 605556 |
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